CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039881
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein transport protein Sec23A 
Protein Synonyms/Alias
  
Gene Name
 SEC23A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
46AALFTPLKERPDLPPubiquitination[1, 2, 3]
81CQVDYRAKLWACNFCubiquitination[2]
156LGCEGISKSYVFRGTubiquitination[2]
169GTKDLSAKQLQEMLGubiquitination[2, 4]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 736 AA 
Protein Sequence
MTTYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPVAA LFTPLKERPD LPPIQYEPVL 60
CSRTTCRAVL NPLCQVDYRA KLWACNFCYQ RNQRGPQMPL IFLYVVDTCM EDEDLQALKE 120
SMQMSLSLLP PTALVGLITF GRMVQVHELG CEGISKSYVF RGTKDLSAKQ LQEMLGLSKV 180
PLTQATRGPQ VQQPPPSNRF LQPVQKIDMN LTDLLGELQR DPWPVPQGKR PLRSSGVALS 240
IAVGLLECTF PNTGARIMMF IGGPATQGPG MVVGDELKTP IRSWHDIDKD NAKYVKKGTK 300
HFEALANRAA TTGHVIDIYA CALDQTGLLE MKCCPNLTGG YMVMGDSFNT SLFKQTFQRV 360
FTKDMHGQFK MGFGGTLEIK TSREIKISGA IGPCVSLNSK GPCVSENEIG TGGTCQWKIC 420
GLSPTTTLAI YFEVVNQHNA PIPQGGRGAI QFVTQYQHSS GQRRIRVTTI ARNWADAQTQ 480
IQNIAASFDQ EAAAILMARL AIYRAETEEG PDVLRWLDRQ LIRLCQKFGE YHKDDPSSFR 540
FSETFSLYPQ FMFHLRRSSF LQVFNNSPDE SSYYRHHFMR QDLTQSLIMI QPILYAYSFS 600
GPPEPVLLDS SSILADRILL MDTFFQILIY HGETIAQWRK SGYQDMPEYE NFRHLLQAPV 660
DDAQEILHSR FPMPRYIDTE HGGSQARFLL SKVNPSQTHN NMYAWGQESG APILTDDVSL 720
QVFMDHLKKL AVSSAA 736 
Gene Ontology
 GO:0030127; C:COPII vesicle coat; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR007123; Gelsolin_dom.
 IPR006900; Sec23/24_helical_dom.
 IPR006896; Sec23/24_trunk_dom.
 IPR012990; Sec23_24_beta_S.
 IPR002035; VWF_A.
 IPR006895; Znf_Sec23_Sec24. 
Pfam
 PF00626; Gelsolin
 PF08033; Sec23_BS
 PF04815; Sec23_helical
 PF04811; Sec23_trunk
 PF04810; zf-Sec23_Sec24 
SMART
  
PROSITE
  
PRINTS