UniProt Accession

 TBL1X_HUMAN; O60907; A8K044; A8K4J7; Q86UY2 

Genbank Protein ID

 Y12781; AK289409; AK290962; AC003036; BC032708; BC052304 

Genbank Nucleotide ID

 CAA73319.1; BAF82098.1; BAF83651.1; AAH32708.1; AAH52304.1 

Protein Name

 F-box-like/WD repeat-containing protein TBL1X 

Protein Synonyms/Alias

 SMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked 

Gene Name

 TBL1X 

Gene Synonyms/Alias

 TBL1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
560	CWNARGDKVGASASD	sumoylation	[1]

Reference

 [1] Reversible SUMOylation of TBL1-TBLR1 regulates β-catenin-mediated Wnt signaling.
 Choi HK, Choi KC, Yoo JY, Song M, Ko SJ, Kim CH, Ahn JH, Chun KH, Yook JI, Yoon HG.
 Mol Cell. 2011 Jul 22;43(2):203-16. [PMID: 21777810] 

Functional Description

 F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. 

Sequence Annotation

 DOMAIN 55 87 LisH.
 DOMAIN 92 137 F-box-like.
 REPEAT 230 269 WD 1.
 REPEAT 286 325 WD 2.
 REPEAT 327 366 WD 3.
 REPEAT 369 409 WD 4.
 REPEAT 410 449 WD 5.
 REPEAT 452 500 WD 6.
 REPEAT 503 542 WD 7.
 REPEAT 544 576 WD 8.  

Keyword

 3D-structure; Activator; Alternative splicing; Complete proteome; Deafness; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation pathway; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 577 AA 

Protein Sequence

Gene Ontology

 GO:0005876; C:spindle microtubule; IDA:UniProtKB.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0017053; C:transcriptional repressor complex; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0042393; F:histone binding; IDA:UniProtKB.
 GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IMP:UniProtKB.
 GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.
 GO:0045444; P:fat cell differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IMP:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR006594; LisH_dimerisation.
 IPR013720; LisH_dimerisation_subgr.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF08513; LisH
 PF00400; WD40 

SMART

 SM00667; LisH
 SM00320; WD40 

PROSITE

 PS50896; LISH
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.