CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012313
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cGMP-inhibited 3',5'-cyclic phosphodiesterase A 
Protein Synonyms/Alias
 Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A 
Gene Name
 PDE3A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
467RDRSTSIKLQEAPSSubiquitination[1]
489PVMMTLTKSRSFTSSubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (By similarity). 
Sequence Annotation
 REGION 728 1086 Catalytic (By similarity).
 ACT_SITE 752 752 Proton donor (By similarity).
 METAL 756 756 Divalent metal cation 1 (By similarity).
 METAL 836 836 Divalent metal cation 1 (By similarity).
 METAL 837 837 Divalent metal cation 1 (By similarity).
 METAL 837 837 Divalent metal cation 2 (By similarity).
 METAL 950 950 Divalent metal cation 1 (By similarity).
 MOD_RES 312 312 Phosphoserine.
 MOD_RES 495 495 Phosphoserine (By similarity).
 MOD_RES 520 520 Phosphoserine.  
Keyword
 3D-structure; cAMP; cGMP; Complete proteome; Direct protein sequencing; Hydrolase; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1141 AA 
Protein Sequence
MAVPGDAARV RDKPVHSGVS QAPTAGRDCH HRADPASPRD SGCRGCWGDL VLQPLRSSRK 60
LSSALCAGSL SFLLALLVRL VRGEVGCDLE QCKEAAAAEE EEAAPGAEGG VFPGPRGGAP 120
GGGARLSPWL QPSALLFSLL CAFFWMGLYL LRAGVRLPLA VALLAACCGG EALVQIGLGV 180
GEDHLLSLPA AGVVLSCLAA ATWLVLRLRL GVLMIALTSA VRTVSLISLE RFKVAWRPYL 240
AYLAGVLGIL LARYVEQILP QSAEAAPREH LGSQLIAGTK EDIPVFKRRR RSSSVVSAEM 300
SGCSSKSHRR TSLPCIPREQ LMGHSEWDHK RGPRGSQSSG TSITVDIAVM GEAHGLITDL 360
LADPSLPPNV CTSLRAVSNL LSTQLTFQAI HKPRVNPVTS LSENYTCSDS EESSEKDKLA 420
IPKRLRRSLP PGLLRRVSST WTTTTSATGL PTLEPAPVRR DRSTSIKLQE APSSSPDSWN 480
NPVMMTLTKS RSFTSSYAIS AANHVKAKKQ SRPGALAKIS PLSSPCSSPL QGTPASSLVS 540
KISAVQFPES ADTTAKQSLG SHRALTYTQS APDLSPQILT PPVICSSCGR PYSQGNPADE 600
PLERSGVATR TPSRTDDTAQ VTSDYETNNN SDSSDIVQNE DETECLREPL RKASACSTYA 660
PETMMFLDKP ILAPEPLVMD NLDSIMEQLN TWNFPIFDLV ENIGRKCGRI LSQVSYRLFE 720
DMGLFEAFKI PIREFMNYFH ALEIGYRDIP YHNRIHATDV LHAVWYLTTQ PIPGLSTVIN 780
DHGSTSDSDS DSGFTHGHMG YVFSKTYNVT DDKYGCLSGN IPALELMALY VAAAMHDYDH 840
PGRTNAFLVA TSAPQAVLYN DRSVLENHHA AAAWNLFMSR PEYNFLINLD HVEFKHFRFL 900
VIEAILATDL KKHFDFVAKF NGKVNDDVGI DWTNENDRLL VCQMCIKLAD INGPAKCKEL 960
HLQWTDGIVN EFYEQGDEEA SLGLPISPFM DRSAPQLANL QESFISHIVG PLCNSYDSAG 1020
LMPGKWVEDS DESGDTDDPE EEEEEAPAPN EEETCENNES PKKKTFKRRK IYCQITQHLL 1080
QNHKMWKKVI EEEQRLAGIE NQSLDQTPQS HSSEQIQAIK EEEEEKGKPR GEEIPTQKPD 1140
Q 1141 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IEA:Compara.
 GO:0030552; F:cAMP binding; IEA:Compara.
 GO:0004119; F:cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.
 GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.
 GO:0071321; P:cellular response to cGMP; IDA:UniProtKB.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB.
 GO:0019934; P:cGMP-mediated signaling; IMP:UniProtKB.
 GO:0016101; P:diterpenoid metabolic process; IEA:Compara.
 GO:0006629; P:lipid metabolic process; TAS:ProtInc.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0043116; P:negative regulation of vascular permeability; IMP:UniProtKB.
 GO:0001556; P:oocyte maturation; IEA:Compara.
 GO:0060282; P:positive regulation of oocyte development; IEA:Compara.
 GO:0043117; P:positive regulation of vascular permeability; IMP:UniProtKB.
 GO:0040020; P:regulation of meiosis; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara. 
Interpro
 IPR003607; HD/PDEase_dom.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 
Pfam
 PF00233; PDEase_I 
SMART
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS