CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024554
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein strawberry notch 
Protein Synonyms/Alias
  
Gene Name
 sno 
Gene Synonyms/Alias
 CG44436 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
85VVGNNKIKPISLLRIacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
 Notch pathway component, may contribute to the specificity between lateral and inductive Notch signaling pathways in the wing disk. Required during many developmental stages including oogenesis, embryogenesis and imaginal development of the eye, wing and leg. Ebi and sno regulate EGFR-dependent Delta transcription in the developing eye, by antagonizing a repressor function of Suppressor of Hairless (Su(H)). They are required in the R-cells for normal cone cell development. 
Sequence Annotation
 MOD_RES 24 24 Phosphoserine.
 MOD_RES 26 26 Phosphoserine.
 MOD_RES 1109 1109 Phosphoserine.
 MOD_RES 1111 1111 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Notch signaling pathway; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1833 AA 
Protein Sequence
MTSKKRKTLL DADDDNDNFD EDDSGSDFDD DEDPDQIEVP GGGRDLNTAV TYAQNIRSGV 60
GVAPKGGIPI PISGAKIVVG NNKIKPISLL RINNNNNNIV TSVNNRNNNN IISTNGSSNN 120
NNNSINNNSQ IIKTTTVTTT PTTVGATPTV GGVALGGKLT VIPIAGRNVA LDNNLSNMPK 180
KLNNMVTAMG SPAARSSGNA GTTGSSQGGA IGSTSSYLNS LTTNELMNLA AYVAAKGSNA 240
PPPPPPSTAA NSVRHSPTGG IPNPGGNFFG GSAAASTSAS AANFNMAASL LAQIRIMDST 300
ENAIVNDVVK YERIEIPLET SSINTLPPDA SNWDALQKEI NLKVAETMKS FYREHSKAIY 360
KMEQLIIDRL GPETSHNSNS EIKEIAELMR RLVNHVENME PVFKLEVVES TLLQKPDSSM 420
GSSGGGTKTC GSREMAESVP AIVIFSNLTF NVQTISEKDF LVAQAKKRHK PGCMSYAGGA 480
SQIRALKVAG NIGGVGNNQK PPPIATTPGS GGPAGGAPGS GVKGNNSMME AVQKLIAMNP 540
EYLTSGIPNT VFQMFMQSMQ RPQATPSPNQ PMNPGAMVTS AAAAAAHASA VAYVQQEEDE 600
VDYEEMGVAE TYADYWPAKL KLGKKHPDAV VETASLSSVE PCDVYYKLSL PLETINSGHL 660
SALQLESITY ASQAHDHLLP DGSRAGFLIG DGAGVGKGRT IAGIIYENYL KGRKKALWIS 720
VSNDLKYDAE RDLSDIGATR IEVHALNKFK YAKISSDVNN NCKRGVIFST YSALIGESNN 780
KTGKYRSRFR QLLQWCGEDF EGLIIFDECH KAKNLCPVGS GKPTKTGQTV LELQQKLPKA 840
RVVYASATGA SEPKNMAYMV RLGLWGQGTA FGNFNDFITA VERRGVGAME IVAMDMKLRG 900
MYIARQLSFK GVSFKIEEVP LSKEFRKIYD QSVELWVEAM QKFTEAAELI DAESRMKKTM 960
WGQFWSSHQR FFKYLCIAAK VNHAVLVARE SIKYGKCVVI GLQSTGEART LDQLERDDGE 1020
LTDFVSTAKG VFQSFVERHF PAPDRNRINR ILGLYDETPS LSSVADSTSS LSNNSNITTA 1080
AGKRKGSNNN DNRSTKIKKK KRSGSWECSD SEDENTDMKR NRKRDGGNSN SDSDEANSDD 1140
DLKSDIDDED EDHDVDSDQR SVASDASSDF NPFFSGSDSD IDPWVNARSK KSKKAQKKSK 1200
KKVKKEKTKK EITTSSATDP SGSTAMSATV VAALNAVKNR KSQLSTQDKI QDLLQKKQEL 1260
KGTVTPVGVN GVKLNYGPPP KDAIERACTM KEELLRKIER LGARLPPNTL DQLIDELGGP 1320
DNVAEMTGRR GRVVQTDDGS IQYESRTESD VPLETLNITE KQRFMDGEKD VAIISEAASS 1380
GISLQSDRRV FNQRRRVHIT LELPWSADRA IQQFGRTHRS NQVNAPEYIF LISDLAGERR 1440
FASTVAKRLE SLGALTHGDR RATETRDLSQ FNIDNKYGRQ ALETVMRTIM GYESPLVPPP 1500
TDYSGEFFKD IAGALVGVGI IVNSESHPGV LSLDKDYNNI SKFLNRILGC PVDLQNRLFK 1560
YFTDTMTAII QQAKRGGRFD LGILDLGAAG ENVTRVRLIR FVRKHATGVA PTEMHTVRVE 1620
RGMIWQEAID KYADLFNENE GFYLSHQLRN QKRTAIMVVI LESRNSSSTS STTDLDSGSK 1680
KKKTHSKKEI MCQIYRPNTG LQVRHESLFE LEKKYRKVAS EEAEPHWTEQ YDASVNTCSH 1740
AYWNGNCRNV SLGNDCEVGL RQRLYHVLAG SVLSVWGRVE HILNTRSNSK MQVIRMKTTE 1800
GEKIVGTLIP KSCFEPLVAD LRSDSEKQEE FNY 1833 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0007219; P:Notch signaling pathway; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
 GO:0048190; P:wing disc dorsal/ventral pattern formation; IMP:UniProtKB. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR026937; SBNO_Helicase_C_dom.
 IPR026741; SNO-like. 
Pfam
 PF13871; Helicase_C_4 
SMART
  
PROSITE
  
PRINTS