UniProt Accession

 ADIRF_HUMAN; Q15847 

Genbank Protein ID

 D45370; AL136982; BC004471 

Genbank Nucleotide ID

 BAA08226.1; AAH04471.1 

Protein Name

 Adipogenesis regulatory factor 

Protein Synonyms/Alias

 Adipogenesis factor rich in obesity; Adipose most abundant gene transcript 2 protein; Adipose-specific protein 2; apM-2 

Gene Name

 ADIRF 

Gene Synonyms/Alias

 AFRO; APM2; C10orf116 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	KAMDQLAKTTQETID	ubiquitination	[1, 2]
56	TTQETIDKTANQASD	ubiquitination	[1]
70	DTFSGIGKKFGLLK*	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. 

Sequence Annotation

  

Keyword

 Complete proteome; Differentiation; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 76 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0072719; P:cellular response to cisplatin; IDA:UniProtKB.
 GO:0071478; P:cellular response to radiation; IDA:UniProtKB.
 GO:0045600; P:positive regulation of fat cell differentiation; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:2001023; P:regulation of response to drug; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS