UniProt Accession

 PTGES_HUMAN; O14684; O14900; Q5SZC0 

Genbank Protein ID

 AF010316; AF027740; AJ271802; AJ271803; AJ271804; AK311947; EF543149; AL590369; AL592219; AL592219; AL590369; BC008280 

Genbank Nucleotide ID

 AAC39534.1; AAB82299.1; CAB72099.1; CAB72099.1; CAB72099.1; BAG34888.1; ABQ01233.1; CAI14506.1; CAI14506.1; CAI16116.1; CAI16116.1; AAH08280.1 

Protein Name

 Prostaglandin E synthase 

Protein Synonyms/Alias

 Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein 

Gene Name

 PTGES 

Gene Synonyms/Alias

 MGST1L1; MPGES1; PGES; PIG12 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
120	HTVAYLGKLRAPIRS	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). 

Sequence Annotation

 REGION 28 38 Glutathione binding.
 REGION 70 77 Glutathione binding.
 REGION 110 113 Glutathione binding.
 BINDING 117 117 Glutathione.
 BINDING 126 126 Glutathione.
 BINDING 130 130 Glutathione.
 BINDING 134 134 Glutathione.  

Keyword

 3D-structure; Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Isomerase; Lipid biosynthesis; Lipid metabolism; Membrane; Prostaglandin biosynthesis; Prostaglandin metabolism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0005641; C:nuclear envelope lumen; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0043295; F:glutathione binding; IDA:UniProtKB.
 GO:0050220; F:prostaglandin-E synthase activity; IDA:UniProtKB.
 GO:0002526; P:acute inflammatory response; IEA:Compara.
 GO:0002544; P:chronic inflammatory response; IEA:Compara.
 GO:0019371; P:cyclooxygenase pathway; TAS:Reactome.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0007165; P:signal transduction; NAS:ProtInc. 

Interpro

 IPR023352; MAPEG-like_dom.
 IPR001129; Membr-assoc_MAPEG. 

Pfam

 PF01124; MAPEG 

SMART

  

PROSITE

  

PRINTS