CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018472
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DDB1- and CUL4-associated factor 11 
Protein Synonyms/Alias
 WD repeat-containing protein 23 
Gene Name
 Dcaf11 
Gene Synonyms/Alias
 D14Ucla1; Wdr23 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
110ELEYNEIKTQVGLATubiquitination[1]
375RYLISNSKDQTIKLWubiquitination[1]
414YRWQQVPKIAWKKLKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). 
Sequence Annotation
 REPEAT 170 210 WD 1.
 REPEAT 216 258 WD 2.
 REPEAT 263 302 WD 3.
 REPEAT 305 345 WD 4.
 REPEAT 353 392 WD 5.
 REPEAT 435 480 WD 6.
 REPEAT 481 520 WD 7.
 MOD_RES 21 21 Phosphoserine.
 MOD_RES 73 73 Phosphoserine.
 MOD_RES 75 75 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 549 AA 
Protein Sequence
MGSRNSSSAG SGSLEPSEGL SRRGTGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG 60
RGAANLQLIQ ALSDSEEEHD SAWDGRLGDR YNPPVDATPD TRELEYNEIK TQVGLATGRL 120
GLRRTALQQS FPQMLHQRER GLCHRGSFSL GEQSRVMSHF LPNDLSFTDT YSQKAFCGIY 180
SKDGQIFMSA CQDQTIRLYD CRYGRFHKFK SIKARDVGWS VLDVAFTPDG NHFLYSSWSD 240
YIHICNIYGE GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT 300
LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA LAGHQDGITF 360
IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRLAA TQQNWDYRWQ QVPKIAWKKL 420
KLPGDSSLMT YRGHGVLHTL IRCRFSPAHS TGQQFIYSGC STGKVVVYDL LSGHIVKKLT 480
NHKACVRDVS WHPFEEKIVS SSWDGNLRLW QYRQAEYFQD DMPESDMNRV CSSGPTPVPC 540
PSVAFSSPQ 549 
Gene Ontology
 GO:0080008; C:Cul4-RING ubiquitin ligase complex; ISS:UniProtKB.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom.
 IPR017399; WD_repeat_p23. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.