CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018871
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hermansky-Pudlak syndrome 1 protein 
Protein Synonyms/Alias
  
Gene Name
 HPS1 
Gene Synonyms/Alias
 HPS 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
513VQRLMREKLTDWKDFubiquitination[1]
518REKLTDWKDFLLVKSubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Component of multiple cytoplasmic organelles. Apparently crucial for their normal development and function. May be involved in intracellular protein sorting. 
Sequence Annotation
 REPEAT 45 51 [DE]-X(4)-L-L 1.
 REPEAT 147 153 [DE]-X(4)-L-L 2.
 REPEAT 516 522 [DE]-X(4)-L-L 3.
 REPEAT 644 650 [DE]-X(4)-L-L 4.
 MOTIF 698 700 Melanosome targeting signal (Potential).  
Keyword
 Albinism; Alternative splicing; Complete proteome; Disease mutation; Hermansky-Pudlak syndrome; Polymorphism; Reference proteome; Repeat; Sensory transduction; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 700 AA 
Protein Sequence
MKCVLVATEG AEVLFYWTDQ EFEESLRLKF GQSENEEEEL PALEDQLSTL LAPVIISSMT 60
MLEKLSDTYT CFSTENGNFL YVLHLFGECL FIAINGDHTE SEGDLRRKLY VLKYLFEVHF 120
GLVTVDGHLI RKELRPPDLA QRVQLWEHFQ SLLWTYSRLR EQEQCFAVEA LERLIHPQLC 180
ELCIEALERH VIQAVNTSPE RGGEEALHAF LLVHSKLLAF YSSHSASSLR PADLLALILL 240
VQDLYPSEST AEDDIQPSPR RARSSQNIPV QQAWSPHSTG PTGGSSAETE TDSFSLPEEY 300
FTPAPSPGDQ SSGSTIWLEG GTPPMDALQI AEDTLQTLVP HCPVPSGPRR IFLDANVKES 360
YCPLVPHTMY CLPLWQGINL VLLTRSPSAP LALVLSQLMD GFSMLEKKLK EGPEPGASLR 420
SQPLVGDLRQ RMDKFVKNRG AQEIQSTWLE FKAKAFSKSE PGSSWELLQA CGKLKRQLCA 480
IYRLNFLTTA PSRGGPHLPQ HLQDQVQRLM REKLTDWKDF LLVKSRRNIT MVSYLEDFPG 540
LVHFIYVDRT TGQMVAPSLN CSQKTSSELG KGPLAAFVKT KVWSLIQLAR RYLQKGYTTL 600
LFQEGDFYCS YFLWFENDMG YKLQMIEVPV LSDDSVPIGM LGGDYYRKLL RYYSKNRPTE 660
AVRCYELLAL HLSVIPTDLL VQQAGQLARR LWEASRIPLL 700 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005764; C:lysosome; TAS:ProtInc.
 GO:0007596; P:blood coagulation; IEA:Compara.
 GO:0048069; P:eye pigmentation; IEA:Compara.
 GO:0007040; P:lysosome organization; TAS:ProtInc.
 GO:0030318; P:melanocyte differentiation; IEA:Compara.
 GO:0032816; P:positive regulation of natural killer cell activation; IEA:Compara.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara.
 GO:0033299; P:secretion of lysosomal enzymes; IEA:Compara.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW. 
Interpro
 IPR026053; HPS1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS