UniProt Accession

 IFT57_HUMAN; Q9NWB7; Q96DA9 

Genbank Protein ID

 AF245220; AF139576; AB014762; AK001009; CR457251; CH471052; BC009690; BC011899 

Genbank Nucleotide ID

 AAK28373.1; AAK13588.1; BAB87803.1; BAA91466.1; CAG33532.1; EAW79730.1; AAH09690.2; AAH11899.1 

Protein Name

 Intraflagellar transport protein 57 homolog 

Protein Synonyms/Alias

 Dermal papilla-derived protein 8; Estrogen-related receptor beta-like protein 1; HIP1-interacting protein; MHS4R2 

Gene Name

 IFT57 

Gene Synonyms/Alias

 DERP8; ESRRBL1; HIPPI 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
305	EKISSREKYINNQLE	ubiquitination	[1, 2]
329	QAQLSEAKERYQQGN	ubiquitination	[1, 2]
384	KQSLTKLKQETVEMD	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. 

Sequence Annotation

 REGION 335 426 pDED.  

Keyword

 Apoptosis; Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; DNA-binding; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 429 AA 

Protein Sequence

Gene Ontology

 GO:0044292; C:dendrite terminus; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005932; C:microtubule basal body; ISS:UniProtKB.
 GO:0032391; C:photoreceptor connecting cilium; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR019530; Intra-flagellar_transport_57. 

Pfam

 PF10498; IFT57 

SMART

  

PROSITE

  

PRINTS