CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043668
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein-L-isoaspartate O-methyltransferase 
Protein Synonyms/Alias
  
Gene Name
 PCMT1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
62VCLAMAWKSGGASHSubiquitination[1]
255QMLEQYDKLQDGSIKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 286 AA 
Protein Sequence
MPGARSGGSG GDGSNSGSYS GDASGAVTVW EVVSLLGKLL GTVVALKVVL YLLRVCLAMA 60
WKSGGASHSE LIHNLRKNGI IKTDKVFEVM LATDRSHYAK CNPYMDSPQS IGFQATISAP 120
HMHAYALELL FDQLHEGAKA LDVGSGSGIL TACFARMVGC TGKVIGIDHI KELVDDSVNN 180
VRKDDPTLLS SGRVQLVVGD GRMGYAEEAP YDAIHVGAAA PVVPQALIDQ LKPGGRLILP 240
VGPAGGNQML EQYDKLQDGS IKMKPLMGVI YVPLTDKEKQ WSRDEL 286 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:EC.
 GO:0046498; P:S-adenosylhomocysteine metabolic process; IEA:Compara.
 GO:0046500; P:S-adenosylmethionine metabolic process; IEA:Compara. 
Interpro
 IPR000682; PCMT. 
Pfam
 PF01135; PCMT 
SMART
  
PROSITE
 PS01279; PCMT 
PRINTS