CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040838
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 PCMTD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
47DYYLEEFKENAYKDLubiquitination[1]
124VIEYAKQKLDFFIRTubiquitination[2, 3]
171YCGAGVQKEHEEYMKubiquitination[3]
182EYMKNLLKVGGILVMubiquitination[3]
194LVMPLEEKLTKITRTubiquitination[1]
197PLEEKLTKITRTGPSubiquitination[3]
229PCHSESGKSRLVQLRubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 282 AA 
Protein Sequence
MGGAVSAGED NDELIDNLKE AQYIRTELVE QAFRAIDRAD YYLEEFKENA YKDLAWKHGN 60
IHLSAPCIYS EVMEALDLQP GLSFLNLGSG TGYLSSMVGL ILGPFGVNHG VELHSDVIEY 120
AKQKLDFFIR TSDSFDKFDF CEPSFVTGNC LEISPDCSQY DRVYCGAGVQ KEHEEYMKNL 180
LKVGGILVMP LEEKLTKITR TGPSAWETKK ILAVSFAPLI QPCHSESGKS RLVQLRSPSF 240
VQGWSVVVLS QLTAASTFQA EAILPSQSPT WLTLQVLATM PN 282 
Gene Ontology
 GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:InterPro. 
Interpro
 IPR000682; PCMT. 
Pfam
 PF01135; PCMT 
SMART
  
PROSITE
  
PRINTS