| Tag | Content |
|---|
| CPLM ID | CPLM-010325 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sensor kinase CusS |
Protein Synonyms/Alias | |
Gene Name | cusS |
Gene Synonyms/Alias | ybcZ; b0570; JW5082 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 226 | QIQNITSKDLDVRLD | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Activates CusR by phosphorylation. |
Sequence Annotation | DOMAIN 208 260 HAMP.
DOMAIN 268 480 Histidine kinase.
MOD_RES 271 271 Phosphohistidine; by autocatalysis (By |
Keyword | ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; Copper; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Two-component regulatory system. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 480 AA |
Protein Sequence | MVSKPFQRPF SLATRLTFFI SLATIAAFFA FAWIMIHSVK VHFAEQDIND LKEISATLER 60
VLNHPDETQA RRLMTLEDIV SGYSNVLISL ADSQGKTVYH SPGAPDIREF TRDAIPDKDA 120
QGGEVYLLSG PTMMMPGHGH GHMEHSNWRM INLPVGPLVD GKPIYTLYIA LSIDFHLHYI 180
NDLMNKLIMT ASVISILIVF IVLLAVHKGH APIRSVSRQI QNITSKDLDV RLDPQTVPIE 240
LEQLVLSFNH MIERIEDVFT RQSNFSADIA HEIRTPITNL ITQTEIALSQ SRSQKELEDV 300
LYSNLEELTR MAKMVSDMLF LAQADNNQLI PEKKMLNLAD EVGKVFDFFE ALAEDRGVEL 360
RFVGDKCQVA GDPLMLRRAL SNLLSNALRY TPTGETIVVR CQTVDHLVQV IVENPGTPIA 420
PEHLPRLFDR FYRVDPSRQR KGEGSGIGLA IVKSIVVAHK GTVAVTSDAR GTRFVITLPA 480 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016020; C:membrane; NAS:EcoliWiki. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0009927; F:histidine phosphotransfer kinase activity; IDA:EcoCyc. GO:0000155; F:phosphorelay sensor kinase activity; IDA:EcoliWiki. GO:0071280; P:cellular response to copper ion; IMP:EcoCyc. GO:0071292; P:cellular response to silver ion; IEP:EcoCyc. GO:0010628; P:positive regulation of gene expression; IMP:EcoCyc. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |