CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012175
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Apoptosis-stimulating of p53 protein 2 
Protein Synonyms/Alias
 Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2 
Gene Name
 TP53BP2 
Gene Synonyms/Alias
 ASPP2; BBP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29QQQLLATKEQRLKFLubiquitination[1]
101MNNLFQQKQRELVLAubiquitination[1]
111ELVLAVSKVEELTRQubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. 
Sequence Annotation
 REPEAT 958 990 ANK 1.
 REPEAT 991 1023 ANK 2.
 DOMAIN 1057 1119 SH3.
 REGION 332 348 Interaction with APPBP1.
 REGION 876 1128 Mediates interaction with APC2.
 MOTIF 866 875 SH3-binding (Potential).
 MOD_RES 480 480 Phosphoserine.
 MOD_RES 556 556 Phosphoserine.
 MOD_RES 572 572 Phosphoserine.
 MOD_RES 698 698 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; ANK repeat; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; SH3 domain; SH3-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1128 AA 
Protein Sequence
MDLTLAELQE MASRQQQQIE AQQQLLATKE QRLKFLKQQD QRQQQQVAEQ EKLKRLKEIA 60
ENQEAKLKKV RALKGHVEQK RLSNGKLVEE IEQMNNLFQQ KQRELVLAVS KVEELTRQLE 120
MLKNGRIDSH HDNQSAVAEL DRLYKELQLR NKLNQEQNAK LQQQRECLNK RNSEVAVMDK 180
RVNELRDRLW KKKAALQQKE NLPVSSDGNL PQQAASAPSR VAAVGPYIQS STMPRMPSRP 240
ELLVKPALPD GSLVIQASEG PMKIQTLPNM RSGAASQTKG SKIHPVGPDW SPSNADLFPS 300
QGSASVPQST GNALDQVDDG EVPLREKEKK VRPFSMFDAV DQSNAPPSFG TLRKNQSSED 360
ILRDAQVANK NVAKVPPPVP TKPKQINLPY FGQTNQPPSD IKPDGSSQQL STVVPSMGTK 420
PKPAGQQPRV LLSPSIPSVG QDQTLSPGSK QESPPAAAVR PFTPQPSKDT LLPPFRKPQT 480
VAASSIYSMY TQQQAPGKNF QQAVQSALTK THTRGPHFSS VYGKPVIAAA QNQQQHPENI 540
YSNSQGKPGS PEPETEPVSS VQENHENERI PRPLSPTKLL PFLSNPYRNQ SDADLEALRK 600
KLSNAPRPLK KRSSITEPEG PNGPNIQKLL YQRTTIAAME TISVPSYPSK SASVTASSES 660
PVEIQNPYLH VEPEKEVVSL VPESLSPEDV GNASTENSDM PAPSPGLDYE PEGVPDNSPN 720
LQNNPEEPNP EAPHVLDVYL EEYPPYPPPP YPSGEPEGPG EDSVSMRPPE ITGQVSLPPG 780
KRTNLRKTGS ERIAHGMRVK FNPLALLLDS SLEGEFDLVQ RIIYEVDDPS LPNDEGITAL 840
HNAVCAGHTE IVKFLVQFGV NVNAADSDGW TPLHCAASCN NVQVCKFLVE SGAAVFAMTY 900
SDMQTAADKC EEMEEGYTQC SQFLYGVQEK MGIMNKGVIY ALWDYEPQND DELPMKEGDC 960
MTIIHREDED EIEWWWARLN DKEGYVPRNL LGLYPRIKPR QRSLA 1005 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0007417; P:central nervous system development; IEA:Compara.
 GO:0009792; P:embryo development ending in birth or egg hatching; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IDA:UniProtKB.
 GO:0045786; P:negative regulation of cell cycle; TAS:UniProtKB.
 GO:0010212; P:response to ionizing radiation; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001452; SH3_domain.
 IPR013315; Spectrin_alpha_SH3. 
Pfam
 PF00023; Ank
 PF00018; SH3_1 
SMART
 SM00248; ANK
 SM00326; SH3 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50002; SH3 
PRINTS
 PR01887; SPECTRNALPHA.