UniProt Accession

 NUD19_MOUSE; P11930; B2RS21 

Genbank Protein ID

 X04097; BC138674; BC138675 

Genbank Nucleotide ID

 CAA27722.1; AAI38675.1; AAI38676.1 

Protein Name

 Nucleoside diphosphate-linked moiety X motif 19, mitochondrial 

Protein Synonyms/Alias

 Nudix motif 19; Androgen-regulated protein RP2; Testosterone-regulated RP2 protein; RP2p 

Gene Name

 Nudt19 

Gene Synonyms/Alias

 D7Rp2e 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
300	KDSDFLEKNMSTDKK	acetylation	[1]
300	KDSDFLEKNMSTDKK	succinylation	[1]
313	KKTEEIVKEGKVLNR	acetylation	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates. 

Sequence Annotation

 DOMAIN 10 242 Nudix hydrolase.
 MOTIF 97 118 Nudix box.
 MOTIF 355 357 Microbody targeting signal (Potential).
 METAL 112 112 Magnesium or manganese (By similarity).
 METAL 116 116 Magnesium or manganese (By similarity).  

Keyword

 Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Mitochondrion; Peroxisome; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 357 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX
 PS00893; NUDIX_BOX 

PRINTS