CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039059
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA mismatch repair protein Mlh1 
Protein Synonyms/Alias
  
Gene Name
 Mlh1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
273LVESAALKKAIEAVYacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 757 AA 
Protein Sequence
MAFVAGVIRR LDETVVNRIA AGEVIQRPAN AIKEMIENCL DAKSTNIQVI VKEGGLKLIQ 60
IQDNGTGIRK EDLDIVCERF TTSKLQTFED LASISTYGFR GEALASISHV AHVTITTKTA 120
DGKCAYRASY SDGKLQAPPK PCAGNQGTLI TVEDLFYNII TRRKALKNPS EEYGKILEVV 180
GRYSIHNSGI SFSVKKQGET VSDVRTLPNA TTVDNIRSIF GNAVSRELIE VGCEDKTLAF 240
KMNGYISNAN YSVKKCIFLL FINHRLVESA ALKKAIEAVY AAYLPKNTHP FLYLSLEISP 300
QNVDVNVHPT KHEVHFLHEE SILERVQQHI ESKLLGSNSS RMYFTQTLLP GLAGPSGEAV 360
KSTTGIASSS TSGSGDKVHA YQMVRTDSRD QKLDAFMQPV SRRLPSQPQD PVPGNRTEGS 420
PEKAMQKDQE MSELPAAMEA AADSASLERE SVIGASEVAP QRHPSSPGSS RKRHREDSDE 480
EMMENDSRKE MTAACYPRRR IINLTSVLSL QEEINDRGHE TLREMLRNHT FVGCVNPQWA 540
LAQHQTKLYL LNTTKLSEEL FYQILIYDFA NFGVLRLSEP APLFDLAMLA LDSPESGWTE 600
EDGPKEGLAE YIVEFLKKKA EMLADYFSVE IDEEGNLIGL PLLIDSYVPP LEGLPIFILR 660
LATEVNWDEE KECFESLSKE CAVFYSIRKQ YILEESALSG QQSDMPGSPS KPWKWTVEHI 720
IYKAFRSHLL PPKHFTEDGN VLQLANLPDL YKVFERC 757 
Gene Ontology
 GO:0005712; C:chiasma; IEA:Compara.
 GO:0001673; C:male germ cell nucleus; IEA:Compara.
 GO:0032389; C:MutLalpha complex; IEA:Compara.
 GO:0000795; C:synaptonemal complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0032137; F:guanine/thymine mispair binding; IEA:Compara.
 GO:0003697; F:single-stranded DNA binding; IEA:Compara.
 GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:Compara.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Compara.
 GO:0045190; P:isotype switching; IEA:Compara.
 GO:0007060; P:male meiosis chromosome segregation; IEA:Compara.
 GO:0043060; P:meiotic metaphase I plate congression; IEA:Compara.
 GO:0006298; P:mismatch repair; IEA:Compara.
 GO:0045950; P:negative regulation of mitotic recombination; IEA:Compara.
 GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IEA:Compara.
 GO:0048477; P:oogenesis; IEA:Compara.
 GO:0000712; P:resolution of meiotic recombination intermediates; IEA:Compara.
 GO:0016446; P:somatic hypermutation of immunoglobulin genes; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0051257; P:spindle midzone assembly involved in meiosis; IEA:Compara. 
Interpro
 IPR002099; DNA_mismatch_repair.
 IPR013507; DNA_mismatch_repair_C.
 IPR014762; DNA_mismatch_repair_CS.
 IPR011186; DNA_mismatch_repair_MLH1.
 IPR014763; DNA_mismatch_repair_N.
 IPR003594; HATPase_ATP-bd.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 
Pfam
 PF01119; DNA_mis_repair 
SMART
 SM00387; HATPase_c 
PROSITE
 PS00058; DNA_MISMATCH_REPAIR_1 
PRINTS