CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033124
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Unconventional myosin-VIIb 
Protein Synonyms/Alias
  
Gene Name
 MYO7B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
634STLGSQFKQSLDQLMubiquitination[1]
1123KQLSENFKTSSLARGubiquitination[1]
1192WLELQAVKSKKHIPIubiquitination[1]
1287PWRIYFRKEFFTPWHubiquitination[1]
1323SGEYSFEKEEELVELubiquitination[1]
1346LGASAESKAVQELLPubiquitination[1]
1359LPSCIPHKLYRTKPPubiquitination[1]
1364PHKLYRTKPPDRWASubiquitination[1]
1379LVTAACAKAPYTQKQubiquitination[1]
1385AKAPYTQKQVTPLAVubiquitination[1]
1513AMALQDRKATDDTTLubiquitination[1]
1524DTTLLAFKKGDLLVLubiquitination[1]
1525TTLLAFKKGDLLVLTubiquitination[1]
1533GDLLVLTKKQGLLASubiquitination[1]
1534DLLVLTKKQGLLASEubiquitination[1]
1553GQNDRTGKTGLVPMAubiquitination[1]
1570YTIPTVTKPSAQLLSubiquitination[1]
1585LLAMSPEKRKLAAQEubiquitination[1]
1605PRPEEPPKEKLHTLEubiquitination[1]
1624EFFRAPEKDMVSMAVubiquitination[1]
1655PLRQPLLKRVHANVDubiquitination[1]
1754GLLPHAQKFIDTRRGubiquitination[1]
1762FIDTRRGKLLAPDCSubiquitination[1]
1774DCSRRIQKVLRTGPRubiquitination[1]
1803NVSRICHKIYFPNDTubiquitination[1]
1850LFIKISDKVISQKEGubiquitination[1]
1855SDKVISQKEGDFFFDubiquitination[1]
1872REVSDWVKKNKPQKEubiquitination[1]
1873EVSDWVKKNKPQKEGubiquitination[1]
1878VKKNKPQKEGAPVTLubiquitination[1]
1903WLNISPGKDVNADTIubiquitination[1]
1919HYHQELPKYLRGFHKubiquitination[1]
1941HLAGLIYKAQFNNDRubiquitination[1]
1956SQLASVPKILRELVPubiquitination[1]
1976LMSSEEWKKSILLAYubiquitination[1]
1977MSSEEWKKSILLAYDubiquitination[1]
1985SILLAYDKHKDKTVEubiquitination[1]
1987LLAYDKHKDKTVEEAubiquitination[1]
1989AYDKHKDKTVEEAKVubiquitination[1]
1995DKTVEEAKVAFLKWIubiquitination[1]
2000EAKVAFLKWICRWPTubiquitination[1]
2044LLIHPKTKDLLTTYPubiquitination[1]
2105QLLSAMNKQRGSKAPubiquitination[1]
2110MNKQRGSKAPALASTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2117 AA 
Protein Sequence
MSGFRLGDHV WLEPPSTHKT GVAIGGIIKE AKPGKVLVED DEGKEHWIRA EDFGVLSPMH 60
PNSVQGVDDM IRLGDLNEAG MVHNLLIRYQ QHKIYTYTGS ILVAVNPFQV LPLYTLEQVQ 120
LYYSRHMGEL PPHVFAIANN CYFSMKRNKR DQCCIISGES GAGKTETTKL ILQFLATISG 180
QHSWIEQQVL EANPILEAFG NAKTIRNDNS SRFGKYIDIY FNPSGVIEGA RIEQFLLEKS 240
RVCRQAPEER NYHIFYCMLM GVSAEDKQLL SLGTPSEYHY LTMGNCTSCE GLNDAKDYAH 300
IRSAMKILQF SDSESWDVIK LLAAILHLGN VGFMASVFEN LDASDVMETP AFPTVMKLLE 360
VQHQELRDCL IKHTILIRGE FVTRSLNIAQ AADRRDAFVK GIYGHLFLWI VKKINAAIFT 420
PPAQDPKNVR RAIGLLDIFG FENFENNSFE QLCINFANEH LQQFFVQHVF TMEQEEYRSE 480
NISWDYIHYT DNRPTLDLLA LKPMSIISLL DEESRFPQGT DLTMLQKLNS VHANNKAFLQ 540
PKNIHDARFG IAHFAGEVYY QAEGFLEKNR DVLSTDILTL VYSSKNKFLR EIFNLELAET 600
KLGHGTIRQA KAGNHLFKSA DSNKRPSTLG SQFKQSLDQL MKILTNCQPY FIRCIKPNEY 660
KKPLLFDREL CLRQLRYSGM METVHIRKSG FPIRYTFEEF SQRFGVLLPN AMRMQLQGKL 720
RQMTLGITDV WLRTDKDWKA GKTKIFLRDH QDTLLEVQRS QVLDRAALSI QKVLRGYRYR 780
KEFLRQRRAA VTLQAWWRGY CNRRNFKLIL VGFERLQAIA RSQPLARQYQ AMRQRTVQLQ 840
ALCRGYLVRQ QVQAKRRAVV VIQAHARGMA ARRNFQQRKA NAPLVIPAEG QKSQGALPAK 900
KRRSIYDTVT DTEMVEKVFG FLPAMIGGQE GQASPHFEDL ESKTQKLLEV DLDTVPMAEE 960
PEEDVDGLAE YTFPKFAVTY FQKSASHTHI RRPLRYPLLY HEDDTDCLAA LVIWNVILRF 1020
MGDLPEPVLY ARSSQQGSSV MRQIHDTLGR EHGAQVPQHS RSAQVASQLN IGEEALEPDG 1080
LGADRPMSNL EKVHFIVGYA ILRPSLRDEI YCQICKQLSE NFKTSSLARG WILLSLCLGC 1140
FPPSERFMKY LLNFIGQGPA TYGPFCAERL RRTYANGVRA EPPTWLELQA VKSKKHIPIQ 1200
VILATGESLT VPVDSASTSR EMCMHIAHKQ GLSDHLGFSL QVAVYDKFWS LGSGRDHMMD 1260
AIARCEQMAQ ERGESQRQSP WRIYFRKEFF TPWHDSREDP VSTELIYRQV LRGVWSGEYS 1320
FEKEEELVEL LARHCYVQLG ASAESKAVQE LLPSCIPHKL YRTKPPDRWA SLVTAACAKA 1380
PYTQKQVTPL AVREQVVDAA RLQWPLLFSR LFEVITLSGP RLPKTQLILA VNWKGLCFLD 1440
QQEKMLLELS FPEVMGLATN REAQGGQRLL LSTMHEEYEF VSPSSVAIAE LVALFLEGLK 1500
ERSIFAMALQ DRKATDDTTL LAFKKGDLLV LTKKQGLLAS ENWTLGQNDR TGKTGLVPMA 1560
CLYTIPTVTK PSAQLLSLLA MSPEKRKLAA QEGQFTEPRP EEPPKEKLHT LEEFSYEFFR 1620
APEKDMVSMA VLPLARARGH LWAYSCEPLR QPLLKRVHAN VDLWDIACQI FATPILRYMG 1680
DYPSRQAWPT LELTDQIFTL ALQHPALQDE VYCQILKQLT HNSNRHSEER GWQLLWLCTG 1740
LFPPSKGLLP HAQKFIDTRR GKLLAPDCSR RIQKVLRTGP RKQPPHQVEV EAAEQNVSRI 1800
CHKIYFPNDT SEMLEVVANT RVRDVCDSIA TRLQLASWEG CSLFIKISDK VISQKEGDFF 1860
FDSLREVSDW VKKNKPQKEG APVTLPYQVY FMRKLWLNIS PGKDVNADTI LHYHQELPKY 1920
LRGFHKCSRE DAIHLAGLIY KAQFNNDRSQ LASVPKILRE LVPENLTRLM SSEEWKKSIL 1980
LAYDKHKDKT VEEAKVAFLK WICRWPTFGS AFFEVKQTSE PSYPDVILIA INRHGVLLIH 2040
PKTKDLLTTY PFTKISSWSS GSTYFHMALG SLGRGSRLLC ETSLGYKMDD LLTSYVQQLL 2100
SAMNKQRGSK APALAST 2117 
Gene Ontology
 GO:0016459; C:myosin complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR019749; Band_41_domain.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR000299; FERM_domain.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR000857; MyTH4_dom.
 IPR027417; P-loop_NTPase.
 IPR011993; PH_like_dom.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00373; FERM_M
 PF00612; IQ
 PF00063; Myosin_head
 PF00784; MyTH4
 PF07653; SH3_2 
SMART
 SM00295; B41
 SM00015; IQ
 SM00242; MYSc
 SM00139; MyTH4
 SM00326; SH3 
PROSITE
 PS50057; FERM_3
 PS50096; IQ
 PS51016; MYTH4
 PS50002; SH3 
PRINTS
 PR00193; MYOSINHEAVY.