UniProt Accession

 FBX22_HUMAN; Q8NEZ5; Q0D2P8; Q6PIL5; Q8IXW3; Q9H824; Q9UKC0 

Genbank Protein ID

 AY005144; AK024048; AC027104; BC032540; BC020204; BC039024; BC041691; AF174602 

Genbank Nucleotide ID

 AAF89095.1; BAB14798.1; AAH32540.1; AAH20204.2; AAH39024.1; AAH41691.1; AAF04523.1 

Protein Name

 F-box only protein 22 

Protein Synonyms/Alias

 F-box protein FBX22p44 

Gene Name

 FBXO22 

Gene Synonyms/Alias

 FBX22 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	VLTFLPAKALLRVAC	ubiquitination	[1]

Reference

 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. 

Sequence Annotation

 DOMAIN 21 67 F-box.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 194 194 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 403 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:Compara.
 GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
 GO:0004842; F:ubiquitin-protein ligase activity; TAS:ProtInc.
 GO:0009267; P:cellular response to starvation; IEA:Compara.
 GO:0006913; P:nucleocytoplasmic transport; IEA:Compara.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0000209; P:protein polyubiquitination; IEA:Compara.
 GO:0010830; P:regulation of myotube differentiation; IEA:Compara.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc. 

Interpro

 IPR001810; F-box_dom_cyclin-like.
 IPR019494; FIST_C_domain. 

Pfam

 PF00646; F-box
 PF10442; FIST_C 

SMART

 SM00256; FBOX 

PROSITE

 PS50181; FBOX 

PRINTS