UniProt Accession

 CP4AE_MOUSE; O35728; A2A975; Q3UER2; Q5EBH0 

Genbank Protein ID

 Y11638; Y11639; Y11640; Y11641; Y11642; AK149392; AK165452; AL627182; BC089609 

Genbank Nucleotide ID

 CAA72345.1; CAA72345.1; CAA72345.1; CAA72345.1; CAA72345.1; BAE28849.1; BAE38193.1; CAM21089.1 

Protein Name

 Cytochrome P450 4A14 

Protein Synonyms/Alias

 CYPIVA14; Cytochrome P450-LA-omega 3; Lauric acid omega-hydroxylase 3 

Gene Name

 Cyp4a14 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
103	LYDPDYVKVVLGRSD	ubiquitination	[1]
153	AFHYDILKPYVKIMA	ubiquitination	[1]
169	SVNIMLDKWEKLDGQ	acetylation	[2]
169	SVNIMLDKWEKLDGQ	ubiquitination	[1]
216	ENSKLYTKAVEDLNN	ubiquitination	[1]
235	RLRNAFYKYNIIYNM	ubiquitination	[1]
268	DGVIKMRKSQLQNEE	ubiquitination	[1]
279	QNEEELQKARKKRHL	ubiquitination	[1]
426	PRFWPNPKVFDPSRF	ubiquitination	[1]
496	ARLVLKSKNGIHLCL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 

Sequence Annotation

 METAL 454 454 Iron (heme axial ligand) (By similarity).
 BINDING 318 318 Heme (covalent; via 1 link) (By  

Keyword

 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 507 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0018685; F:alkane 1-monooxygenase activity; IEA:EC.
 GO:0050544; F:arachidonic acid binding; IEA:Compara.
 GO:0008391; F:arachidonic acid monooxygenase activity; IEA:Compara.
 GO:0052869; F:arachidonic acid omega-hydroxylase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0046456; P:icosanoid biosynthetic process; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0048252; P:lauric acid metabolic process; IEA:Compara.
 GO:0043651; P:linoleic acid metabolic process; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009725; P:response to hormone stimulus; IEA:Compara. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR00385; P450.