Tag | Content |
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CPLM ID | CPLM-018588 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase RNF185 |
Protein Synonyms/Alias | RING finger protein 185 |
Gene Name | Rnf185 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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80 | RQVCPVCKAGISRDK | ubiquitination | [1] | 87 | KAGISRDKVIPLYGR | ubiquitination | [1] | 105 | GQQDPREKTPPRPQG | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (By similarity). |
Sequence Annotation | ZN_FING 39 80 RING-type. |
Keyword | Alternative splicing; Autophagy; Complete proteome; Ligase; Membrane; Metal-binding; Mitochondrion; Mitochondrion outer membrane; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 192 AA |
Protein Sequence | MASKGPSASA STENSNAGGP SGSSNGTGES GGQDSTFECN ICLDTAKDAV ISLCGHLFCW 60 PCLHQWLETR PNRQVCPVCK AGISRDKVIP LYGRGSTGQQ DPREKTPPRP QGQRPEPENR 120 GGFQGFGFGD GGFQMSFGIG AFPFGIFATA FNINDGRPPP AVPGTPQYVD EQFLSRLFLF 180 VALVIMFWLL IA 192 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006914; P:autophagy; IEA:UniProtKB-KW. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
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