CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027762
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-acetylneuraminic acid synthase (Sialic acid synthase) 
Protein Synonyms/Alias
 Protein Nans 
Gene Name
 Nans 
Gene Synonyms/Alias
 mCG_4426 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
52ECGADCAKFQKSELEacetylation[1]
55ADCAKFQKSELEFKFacetylation[1]
61QKSELEFKFNRKALEacetylation[2]
74LERPYTSKHSWGKTYacetylation[2]
79TSKHSWGKTYGEHKRacetylation[1, 2]
290CEMACNEKLGKSVVAacetylation[1, 2, 3]
333DIFNLAGKKVLVTIEacetylation[4]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MPLELELCPG RWVGGKHPCF IIAEIGQNHQ GDIDVAKRMI RTAKECGADC AKFQKSELEF 60
KFNRKALERP YTSKHSWGKT YGEHKRHLEF SHDQYKELQS YAQEIGIFFT ASGMDEMAVE 120
FLHELNVPFF KVGSGDTNNF PYLEKTAKKG RPMVISSGMQ SMDTMKQVYQ IVKPLNPNFC 180
FLQCTSAYPL QPEDANLRVI SEYQKLFPDI PIGYSGHETG IAISVAAVAL GAKVLERHIT 240
LDKTWKGSDH SASLEPGELA ELVRSVRLVE RALGSPTKQL LPCEMACNEK LGKSVVAKVK 300
IPAGTTLTLD MLTVKVGEPK GYPPEDIFNL AGKKVLVTIE EDDTVMEESV ESHSKKIKA 359 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0047444; F:N-acylneuraminate-9-phosphate synthase activity; IDA:MGI.
 GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro. 
Interpro
 IPR006190; AFP_Neu5c_C.
 IPR013785; Aldolase_TIM.
 IPR006013; Antifreeze_III.
 IPR013132; Neu5Ac_N.
 IPR013974; SAF. 
Pfam
 PF03102; NeuB
 PF08666; SAF 
SMART
 SM00858; SAF 
PROSITE
 PS50844; AFP_LIKE 
PRINTS
 PR00357; ANTIFREEZIII.