UniProt Accession

 PANC_ECOLI; P31663; Q2MCG4 

Genbank Protein ID

 L17086; U00096; AP009048 

Genbank Nucleotide ID

 AAA24272.1; AAC73244.1; BAE76042.1 

Protein Name

 Pantothenate synthetase 

Protein Synonyms/Alias

 PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme 

Gene Name

 panC 

Gene Synonyms/Alias

 b0133; JW0129 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
39	NLHDGHMKLVDEAKA	acetylation	[1]
45	MKLVDEAKARADVVV	acetylation	[1]
81	TLQEDCEKLNKRKVD	acetylation	[1, 2]
84	EDCEKLNKRKVDLVF	acetylation	[1]
86	CEKLNKRKVDLVFAP	acetylation	[1]
96	LVFAPSVKEIYPNGT	acetylation	[1]
151	DIACFGEKDFQQLAL	acetylation	[2]
181	GVPIMRAKDGLALSS	acetylation	[1, 2]
199	YLTAEQRKIAPGLYK	acetylation	[1]
206	KIAPGLYKVLSSIAD	acetylation	[1, 2]
214	VLSSIADKLQAGERD	acetylation	[1]
236	AGQELNEKGFRADDI	acetylation	[1, 2]
259	LEVSETSKRAVILVA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. 

Sequence Annotation

 NP_BIND 30 37 ATP (By similarity).
 NP_BIND 149 152 ATP (By similarity).
 NP_BIND 186 189 ATP (By similarity).
 ACT_SITE 37 37 Proton donor (By similarity).
 BINDING 61 61 Beta-alanine (By similarity).
 BINDING 61 61 Pantoate (By similarity).
 BINDING 155 155 Pantoate (By similarity).
 BINDING 178 178 ATP; via amide nitrogen and carbonyl  

Keyword

 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Pantothenate biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004592; F:pantoate-beta-alanine ligase activity; IDA:EcoCyc.
 GO:0033317; P:pantothenate biosynthetic process from valine; IMP:EcoCyc. 

Interpro

 IPR004821; Cyt_trans-like.
 IPR003721; Pantoate_ligase.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF02569; Pantoate_ligase 

SMART

  

PROSITE

  

PRINTS