CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040978
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Zinc finger protein 473 
Protein Synonyms/Alias
  
Gene Name
 ZNF473 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
223WITHTREKPTVHQECubiquitination[1, 2]
300TQPGEHQKTHTDSKSubiquitination[3]
370SECQECGKIFRHSSLubiquitination[1, 2]
473QAIHTAEKPYSCAECubiquitination[1]
500HQKMHTVKTPYECQEubiquitination[1]
529ESVHAREKQGFFVSGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 859 AA 
Protein Sequence
MDFTLGDWEQ LGLEQGDTFW DTALDNCQDL FLLDPPRPNL TSHPDGSEDL EPLAGGSPEA 60
TSPDVTETKN SPLMEDFFEE GFSQEIIEML SKDGFWNSNF GEACIEDTWL DSLLGDPESL 120
LRSDIATNGE SPTECKSHEL KRGLSPVSTV STGEDSMVHN VSEKTLTPAK SKEYRGEFFS 180
YSDHSQQDSV QEGEKPYQCS ECGKSFSGSY RLTQHWITHT REKPTVHQEC EQGFDRNASL 240
SVYPKTHTGY KFYVCNEYGT TFSQSTYLWH QKTHTGEKPC KSQDSDHPPS HDTQPGEHQK 300
THTDSKSYNC NECGKAFTRI FHLTRHQKIH TRKRYECSKC QATFNLRKHL IQHQKTHAAK 360
TTSECQECGK IFRHSSLLIE HQALHAGEEP YKCNERGKSF RHNSTLKIHQ RVHSGEKPYK 420
CSECGKAFHR HTHLNEHRRI HTGYRPHKCQ ECVRSFSRPS HLMRHQAIHT AEKPYSCAEC 480
KETFSDNNRL VQHQKMHTVK TPYECQECGE RFICGSTLKC HESVHAREKQ GFFVSGKILD 540
QNPEQKEKCF KCNKCEKTFS CSKYLTQHER IHTRGVKPFE CDQCGKAFGQ STRLIHHQRI 600
HSRVRLYKWG EQGKAISSAS LIKLQSFHTK EHPFKCNECG KTFSHSAHLS KHQLIHAGEN 660
PFKCSKCDRV FTQRNYLVQH ERTHARKKPL VCNECGKTFR QSSCLSKHQR IHSGEKPYVC 720
DYCGKAFGLS AELVRHQRIH TGEKPYVCQE CGKAFTQSSC LSIHRRVHTG EKPYRCGECG 780
KAFAQKANLT QHQRIHTGEK PYSCNVCGKA FVLSAHLNQH LRVHTQETLY QCQRCQKAFR 840
CHSSLSRHQR VHNKQQYCL 859 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS