CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037853
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Radixin 
Protein Synonyms/Alias
  
Gene Name
 RDX 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
24QLFDQVVKTVGLREVubiquitination[1]
61VTQQDVKKENPLQFKubiquitination[2]
68KENPLQFKFRAKFFPubiquitination[2, 3]
72LQFKFRAKFFPEDVSubiquitination[1, 2, 4]
128AKYGDYNKEIHKPGYubiquitination[2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 148 AA 
Protein Sequence
MDAELEFAIQ PNTTGKQLFD QVVKTVGLRE VWFFGLQYVD SKGYSTWLKL NKKVTQQDVK 60
KENPLQFKFR AKFFPEDVSE ELIQEITQRL FFLQVKEAIL NDEIYCPPET AVLLASYAVQ 120
AKYGDYNKEI HKPGYLANDR LLPQRVLE 148 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0019898; C:extrinsic to membrane; IEA:InterPro.
 GO:0030175; C:filopodium; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0032420; C:stereocilium; IEA:Compara.
 GO:0045176; P:apical protein localization; IEA:Compara.
 GO:0030033; P:microvillus assembly; IEA:Compara. 
Interpro
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR000798; Ez/rad/moesin_like.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N. 
Pfam
 PF00373; FERM_M
 PF09379; FERM_N 
SMART
 SM00295; B41 
PROSITE
 PS00660; FERM_1
 PS50057; FERM_3 
PRINTS
 PR00935; BAND41.
 PR00661; ERMFAMILY.