CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004905
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 2A5 
Protein Synonyms/Alias
 CYPIIA5; Coumarin 7-hydroxylase; Cytochrome P450-15-COH; Cytochrome P450-IIA3.2 
Gene Name
 Cyp2a5 
Gene Synonyms/Alias
 Cyp2a-5 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
142LRDFGVGKRGIEERIubiquitination[1]
162FLIDSFRKTNGAFIDubiquitination[1]
239GPQQQAFKELQGLEDubiquitination[1]
250GLEDFITKKVEHNQRubiquitination[1]
251LEDFITKKVEHNQRTubiquitination[1]
280IRMLEEKKNPNTEFYubiquitination[1]
348PKYEDRMKMPYTEAVubiquitination[1]
379RRVTKDTKFRDFLLPubiquitination[1]
387FRDFLLPKGTEVFPMubiquitination[1]
400PMLGSVLKDPKFFSNubiquitination[1]
403GSVLKDPKFFSNPKDubiquitination[1]
409PKFFSNPKDFNPKHFubiquitination[1]
414NPKDFNPKHFLDDKGubiquitination[1]
420PKHFLDDKGQFKKNDubiquitination[1]
425DDKGQFKKNDAFVPFubiquitination[1]
436FVPFSIGKRYCFGEGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Exhibits a high coumarin 7-hydroxylase activity. 
Sequence Annotation
 METAL 439 439 Iron (heme axial ligand).  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 494 AA 
Protein Sequence
MLTSGLLLVA AVAFLSVLVL MSVWKQRKLS GKLPPGPTPL PFIGNFLQLN TEQMYNSLMK 60
ISQRYGPVFT IYLGPRRIVV LCGQEAVKEA LVDQAEEFSG RGEQATFDWL FKGYGVVFSS 120
GERAKQLRRF SIATLRDFGV GKRGIEERIQ EEAGFLIDSF RKTNGAFIDP TFYLSRTVSN 180
VISSIVFGDR FDYEDKEFLS LLRMMLGSFQ FTATSMGQLY EMFSSVMKHL PGPQQQAFKE 240
LQGLEDFITK KVEHNQRTLD PNSPRDFIDS FLIRMLEEKK NPNTEFYMKN LVLTTLNLFF 300
AGTETVSTTL RYGFLLLMKH PDIEAKVHEE IDRVIGRNRQ PKYEDRMKMP YTEAVIHEIQ 360
RFADMIPMGL ARRVTKDTKF RDFLLPKGTE VFPMLGSVLK DPKFFSNPKD FNPKHFLDDK 420
GQFKKNDAFV PFSIGKRYCF GEGLARMELF LFLTNIMQNF HFKSTQAPQD IDVSPRLVGF 480
ATIPPTYTMS FLSR 494 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0035634; P:response to stilbenoid; IEP:UniProtKB. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008067; Cyt_P450_E_grp-I_CYP2A-like. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR01684; EP450ICYP2A.
 PR00385; P450.