CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019805
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myeloid differentiation primary response protein MyD88 
Protein Synonyms/Alias
  
Gene Name
 MYD88 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
95RLLELLTKLGRDDVLubiquitination[1, 2]
282DYTNPCTKSWFWTRLubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. 
Sequence Annotation
 DOMAIN 54 109 Death.
 DOMAIN 159 296 TIR.
 REGION 110 155 Intermediate domain (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Immunity; Inflammatory response; Innate immunity; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 296 AA 
Protein Sequence
MAAGGPGAGS AAPVSSTSSL PLAALNMRVR RRLSLFLNVR TQVAADWTAL AEEMDFEYLE 60
IRQLETQADP TGRLLDAWQG RPGASVGRLL ELLTKLGRDD VLLELGPSIE EDCQKYILKQ 120
QQEEAEKPLQ VAAVDSSVPR TAELAGITTL DDPLGHMPER FDAFICYCPS DIQFVQEMIR 180
QLEQTNYRLK LCVSDRDVLP GTCVWSIASE LIEKRCRRMV VVVSDDYLQS KECDFQTKFA 240
LSLSPGAHQK RLIPIKYKAM KKEFPSILRF ITVCDYTNPC TKSWFWTRLA KALSLP 296 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0010008; C:endosome membrane; TAS:Reactome.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005123; F:death receptor binding; TAS:ProtInc.
 GO:0070935; P:3'-UTR-mediated mRNA stabilization; IDA:BHF-UCL.
 GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB.
 GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB.
 GO:0032740; P:positive regulation of interleukin-17 production; ISS:BHF-UCL.
 GO:0032747; P:positive regulation of interleukin-23 production; ISS:BHF-UCL.
 GO:0032755; P:positive regulation of interleukin-6 production; ISS:BHF-UCL.
 GO:0050727; P:regulation of inflammatory response; ISS:BHF-UCL.
 GO:0070555; P:response to interleukin-1; IMP:BHF-UCL.
 GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome.
 GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
 GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
 GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.
 GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome.
 GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome.
 GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome. 
Interpro
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR017281; Myelin_different_resp_MyD88.
 IPR000157; TIR_dom. 
Pfam
 PF00531; Death
 PF01582; TIR 
SMART
 SM00005; DEATH
 SM00255; TIR 
PROSITE
 PS50017; DEATH_DOMAIN
 PS50104; TIR 
PRINTS