UniProt Accession

 PTP61_DROME; Q9W0G1; Q27932; Q8SZY3; Q9W0G2 

Genbank Protein ID

 L11250; L11249; L11251; L11249; L11250; L11252; L11253; L14849; AE014296; AE014296; AE014296; AY069713 

Genbank Nucleotide ID

 AAA75348.1; AAA75348.1; AAA75349.1; AAA75349.1; AAA75349.1; AAA75338.1; AAA75339.1; AAA28748.1; AAF47486.1; AAF47487.1; AAN11475.1; AAL39858.1 

Protein Name

 Tyrosine-protein phosphatase non-receptor type 61F 

Protein Synonyms/Alias

 dPTP61F 

Gene Name

 Ptp61F 

Gene Synonyms/Alias

 CG9181 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
365	NGAESIGKELSKDAL	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state. 

Sequence Annotation

 DOMAIN 33 296 Tyrosine-protein phosphatase.
 REGION 237 243 Substrate binding (By similarity).
 ACT_SITE 237 237 Phosphocysteine intermediate (By
 BINDING 203 203 Substrate (By similarity).
 BINDING 281 281 Substrate (By similarity).
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 86 86 Phosphotyrosine.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Membrane; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 548 AA 

Protein Sequence

Gene Ontology

 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0005740; C:mitochondrial envelope; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase.
 GO:0004725; F:protein tyrosine phosphatase activity; IDA:FlyBase.
 GO:0007411; P:axon guidance; IPI:FlyBase.
 GO:0071456; P:cellular response to hypoxia; IMP:FlyBase.
 GO:0007377; P:germ-band extension; IDA:UniProtKB.
 GO:0000278; P:mitotic cell cycle; IMP:FlyBase.
 GO:0046426; P:negative regulation of JAK-STAT cascade; IMP:FlyBase.
 GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:FlyBase.
 GO:0032880; P:regulation of protein localization; IDA:FlyBase.
 GO:0031647; P:regulation of protein stability; IMP:FlyBase. 

Interpro

 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 

Pfam

 PF00102; Y_phosphatase 

SMART

 SM00194; PTPc 

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 

PRINTS

 PR00700; PRTYPHPHTASE.