CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021134
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 C-Jun-amino-terminal kinase-interacting protein 3 
Protein Synonyms/Alias
 JIP-3; JNK-interacting protein 3; JNK MAP kinase scaffold protein 3; JNK/SAPK-associated protein 1; JSAP1; Mitogen-activated protein kinase 8-interacting protein 3; Sunday driver 2 
Gene Name
 Mapk8ip3 
Gene Synonyms/Alias
 Jip3; Jsap1; Syd2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
183VEHIERSKMQQVGGSubiquitination[1]
443NSQLLETKNALNVVKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. 
Sequence Annotation
 MOD_RES 266 266 Phosphothreonine; by MAPK.
 MOD_RES 276 276 Phosphothreonine; by MAPK.
 MOD_RES 287 287 Phosphothreonine; by MAPK.
 MOD_RES 315 315 Phosphoserine; by ROCK1 (By similarity).
 MOD_RES 365 365 Phosphoserine; by ROCK1 (By similarity).
 MOD_RES 366 366 Phosphoserine; by ROCK1 (By similarity).
 MOD_RES 677 677 Phosphoserine.  
Keyword
 Alternative splicing; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Golgi apparatus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1337 AA 
Protein Sequence
MMEIQMDEGG GVVVYQDDYC SGSVMSERVS GLAGSIYREF ERLIHCYDEE VVKELMPLVV 60
NVLENLDSVL SENQEHEVEL ELLREDNEQL LTQYEREKAL RKQAEEKFIE FEDALEQEKK 120
ELQIQVEHYE FQTRQLELKA KNYADQISRL EERESEMKKE YNALHQRHTE MIQTYVEHIE 180
RSKMQQVGGS GQTESSLPGR SPRQSWRKSR KERPTSLNVF PLADGMVRAQ MGGKLVPAGD 240
HWHLSDLGQL QSSSSYQCPN DEMSESGQSS AAATPSTTGT KSNTPTSSVP SAAVTPLNES 300
LQPLGDYVSV TKNNKQAREK RNSRNMEVQV TQEMRNVSIG MGSSDEWSDV QDIIDSTPEL 360
DVCPETRLER TGSSPTQGIV NKAFGINTDS LYHELSTAGS EVIGDVDEGA DLLGEFSVRD 420
DFFGMGKEVG NLLLENSQLL ETKNALNVVK NDLIAKVDQL SGEQEVLKGE LEAAKQAKVK 480
LENRIKELEE ELKRVKSEAV TARREPREEV EDVSSYLCTE LDKIPMAQRR RFTRVEMARV 540
LMERNQYKER LMELQEAVRW TEMIRASREH PSVQEKKKST IWQFFSRLFS SSSSPPPAKR 600
SYPSVNIHYK SPTAAGFSQR RSHALCQISA GSRPLEFFPD DDCTSSARRE QKREQYRQVR 660
EHVRNDDGRL QACGWSLPAK YKQLSPNGGQ EDTRMKNVPV PVYCRPLVEK DPSTKLWCAA 720
GVNLSGWKPH EEDSSNGPKP VPGRDPLTCD REGEGEPKST HPSPEKKKAK ETPEADATSS 780
RVWILTSTLT TSKVVIIDAN QPGTIVDQFT VCNAHVLCIS SIPAASDSDY PPGEMFLDSD 840
VNPEDSGADG VLAGITLVGC ATRCNVPRSN CSSRGDTPVL DKGQGDVATT ANGKVNPSQS 900
TEEATEATEV PDPGPSESEA TTVRPGPLTE HVFTDPAPTP SSSTQPASEN GSESNGTIVQ 960
PQVEPSGELS TTTSSAAPTM WLGAQNGWLY VHSAVANWKK CLHSIKLKDS VLSLVHVKGR 1020
VLVALADGTL AIFHRGEDGQ WDLSNYHLMD LGHPHHSIRC MAVVNDRVWC GYKNKVHVIQ 1080
PKTMQIEKSF DAHPRRESQV RQLAWIGDGV WVSIRLDSTL RLYHAHTHQH LQDVDIEPYV 1140
SKMLGTGKLG FSFVRITALL IAGNRLWVGT GNGVVISIPL TETVVLHRGQ LLGLRANKTS 1200
PTSGEGTRPG GIIHVYGDDS SDKAASSFIP YCSMAQAQLC FHGHRDAVKF FVSVPGNVLA 1260
TLNGSVLDSP SEGPGPAAPA ADAEGQKLKN ALVLSGGEGY IDFRIGDGED DETEECAGDV 1320
NQTKPSLSKA ERSHIIVWQV SYTPE 1345 
Gene Ontology
 GO:0030673; C:axolemma; IDA:MGI.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0000139; C:Golgi membrane; IDA:UniProtKB.
 GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
 GO:0005790; C:smooth endoplasmic reticulum; IDA:MGI.
 GO:0005078; F:MAP-kinase scaffold activity; IDA:BHF-UCL.
 GO:0007257; P:activation of JUN kinase activity; IDA:MGI.
 GO:0007411; P:axon guidance; IMP:MGI.
 GO:0030900; P:forebrain development; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0048286; P:lung alveolus development; IMP:MGI.
 GO:0060425; P:lung morphogenesis; IMP:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI.
 GO:0008104; P:protein localization; IMP:MGI.
 GO:0010468; P:regulation of gene expression; IDA:MGI.
 GO:0007585; P:respiratory gaseous exchange; IMP:MGI.
 GO:0016192; P:vesicle-mediated transport; IDA:UniProtKB. 
Interpro
 IPR019143; JNK/Rab-associated_protein-1_N.
 IPR011047; Quinonprotein_ADH-like_supfam.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF09744; Jnk-SapK_ap_N 
SMART
  
PROSITE
  
PRINTS