CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031145
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CTP synthase 1 
Protein Synonyms/Alias
 cDNA FLJ59392, highly similar to CTP synthase 1 (EC 6.3.4.2) 
Gene Name
 CTPS1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
55RKMLMKWKEMADRYDubiquitination[1]
75CSIALVGKYTKFSDSubiquitination[1, 2]
78ALVGKYTKFSDSYASubiquitination[1, 2, 3, 4]
88DSYASVIKALEHSALubiquitination[1, 2, 3, 5]
100SALAINHKLEIKYIDubiquitination[1, 2, 5]
104INHKLEIKYIDSADLubiquitination[1, 2, 4, 5]
129RYHEAWQKLCSAHGVubiquitination[1]
150GVRGTEGKIQAIAWAubiquitination[1, 2]
229RRTLFQTKNSVMRKLacetylation[6]
229RRTLFQTKNSVMRKLubiquitination[1, 2, 3]
235TKNSVMRKLYGDADYubiquitination[1, 2]
259EVNPVWKKCLEEQGLubiquitination[1, 2]
267CLEEQGLKFVGQDVEubiquitination[1, 2, 5]
304EFLSRPIKPSPPYFGubiquitination[1, 2, 3]
326RLSHYLQKGCRLSPRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 360 AA 
Protein Sequence
MFCHVEPEQV ICVHDVSSIY RVPLLLEEQG VVDYFLRRLD LPIERQPRKM LMKWKEMADR 60
YDRLLETCSI ALVGKYTKFS DSYASVIKAL EHSALAINHK LEIKYIDSAD LEPITSQEEP 120
VRYHEAWQKL CSAHGVLVPG GFGVRGTEGK IQAIAWARNQ KKPFLGVCLG MQLAVVEFSR 180
NVLGWQDANS TEFDPTTSHP VVVDMPEHNP GQMGGTMRLG KRRTLFQTKN SVMRKLYGDA 240
DYLEERHRHR FEVNPVWKKC LEEQGLKFVG QDVEGERMEI VELEDHPFFV GVQYHPEFLS 300
RPIKPSPPYF GLLLASVGRL SHYLQKGCRL SPRDTYSDRS GSSSPDSEIT ELKFPSINHD 360 
Gene Ontology
 GO:0003883; F:CTP synthase activity; IEA:InterPro.
 GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:InterPro. 
Interpro
 IPR004468; CTP_synthase.
 IPR017456; CTP_synthase_N.
 IPR017926; GATASE.
 IPR027417; P-loop_NTPase. 
Pfam
 PF06418; CTP_synth_N
 PF00117; GATase 
SMART
  
PROSITE
 PS51273; GATASE_TYPE_1 
PRINTS