| Tag | Content |
|---|
| CPLM ID | CPLM-014514 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Neurexin-2 |
Protein Synonyms/Alias | Neurexin II-alpha; Neurexin-2-alpha |
Gene Name | Nrxn2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1692 | QSNGAVVKEKAPAAP | ubiquitination | [1] | | 1700 | EKAPAAPKTPSKAKK | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. |
Sequence Annotation | DOMAIN 30 206 Laminin G-like 1.
DOMAIN 202 242 EGF-like 1.
DOMAIN 289 486 Laminin G-like 2.
DOMAIN 493 686 Laminin G-like 3.
DOMAIN 690 727 EGF-like 2.
DOMAIN 732 907 Laminin G-like 4.
DOMAIN 921 1096 Laminin G-like 5.
DOMAIN 1099 1136 EGF-like 3.
DOMAIN 1140 1348 Laminin G-like 6.
METAL 335 335 Calcium (By similarity).
METAL 352 352 Calcium; via carbonyl oxygen (By
METAL 420 420 Calcium; via carbonyl oxygen (By
CARBOHYD 60 60 N-linked (GlcNAc...) (Potential).
CARBOHYD 338 338 N-linked (GlcNAc...) (Potential).
CARBOHYD 844 844 N-linked (GlcNAc...) (Potential).
CARBOHYD 1239 1239 N-linked (GlcNAc...) (Potential).
DISULFID 206 219 By similarity.
DISULFID 213 229 By similarity.
DISULFID 231 241 By similarity.
DISULFID 450 486 By similarity.
DISULFID 657 686 By similarity.
DISULFID 694 705 By similarity.
DISULFID 699 714 By similarity.
DISULFID 716 726 By similarity.
DISULFID 1068 1096 By similarity.
DISULFID 1103 1114 By similarity.
DISULFID 1108 1123 By similarity.
DISULFID 1125 1135 By similarity. |
Keyword | Alternative promoter usage; Alternative splicing; Calcium; Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Metal-binding; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1715 AA |
Protein Sequence | MALGSRWRPP PQLPPLLLLL ALVAGVRGLE FGGGPGQWAR YARWAGAAST GELSFSLRTN 60
ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT LQLDTPVADD RWHMVLLTRD 120
ARRTALAVDG EARAAEVRSK RREMQVASDL FVGGIPPDVR LSALTLSTVK YEPPFRGLLA 180
NLKLGERPPA LLGSQGLRGA AADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF 240
CSEGEHPMEG PAHLTLNSPV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY 300
DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI NLGSGAFEAL 360
VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVNKLHYLV TISVDGILTT TGYTQEDYTM 420
LGSDDFFYIG GSPNTADLPG SPVSNNFMGC LKDVVYKNND FKLELSRLAK EGDPKMKLQG 480
DLSFRCEDVA ALDPVTFESP EAFVALPRWS AKRTGSISLD FRTTEPNGLL LFSQGRRAGA 540
GVGSHSSSQR ADYFAMELLD GYLYLLLDMG SGGIKLRASS RKVNDGEWCH VDFQRDGRKG 600
SISVNSRSTP FLATGESEVL DLESELYLGG LPEGGRVDLP LPPEVWTAAL RAGYVGCVRD 660
LFIDGRSRDL RGLAEAQGAV GVAPFCSRET LKQCASAPCR NGGICREGWN RFVCDCIGTG 720
FLGRVCEREA TVLSYDGSMY MKIMLPNAMH TEAEDVSLRF MSQRAYGLMM ATTSRESADT 780
LRLELDGGQM KLTVNLDCLR VGCAPSAAGK GPETLFAGHK LNDNEWHTVR VVRRGKSLQL 840
SVDNVTVEGQ MAGAHTRLEF HNIETGIMTE RRFISVVPSN FIGHLSGLVF NGQPYMDQCK 900
DGDITYCELN ARFGLRAIVA DPVTFKSRSS YLALATLQAY ASMHLFFQFK TTAPDGLLLF 960
NSGNGNDFIV IELVKGYIHY VFDLGNGPSL MKGNSDKPVN DNQWHNVVVS RDPGNVHTLK 1020
IDSRTVTQHS NGARNLDLKG ELYIGGLSKN MFSNLPKLVA SRDGFQGCLA SVDLNGRLPD 1080
LIADALHRIG QVERGCDGPS TTCTEESCAN QGVCLQQWDG FTCDCTMTSY GGPVCNDPGT 1140
TYIFGKGGAL ITYTWPPNDR PSTRMDRLAV GFSTHQRSAV LVRVDSASGL GDYLQLHIDQ 1200
GTVGVIFNVG TDDITIDEPN AIVSDGKYHV VRFTRSGGNA TLQVDSWPVN ERYPAGNFDN 1260
ERLAIARQRI PYRLGRVVDE WLLDKGRQLT IFNSQAAIKI GGRDQGRPFQ GQVSGLYYNG 1320
LKVLALAAES DPNVRTEGHL RLVGEGPSVL LSAETTATTL LADMATTIME TTTTMATTTT 1380
RRGRSPTMRD STTQNTDDLL VASAECPSDD EDLEECEPST GGELILPIIT EDSLDPPPVA 1440
TRSPFVPPPP TFYPFLTGVG ATQDTLPPPA ARRPSSGGPC QAERDDSDCE EPVEASGFAS 1500
GEVFDSSLPP TDDEDFYTTF PLVTDRTTLL SPRKPAPRPN LRTDGATGAP GVLLAPSAPA 1560
PNLPAGKMNH RDPLQPLLEN PPLGPGVPTA FEPRRPPPLR PGVTSVPGFP RLPTANPTGP 1620
GERGPPGAVE VIRESSSTTG MVVGIVAAAA LCILILLYAM YKYRNRDEGS YQVDQSRNYI 1680
SNSAQSNGAV VKEKAPAAPK TPSKAKKNKD KEYYV 1715 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0050839; F:cell adhesion molecule binding; ISS:BHF-UCL. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. GO:0097116; P:gephyrin clustering; ISS:BHF-UCL. GO:0097118; P:neuroligin clustering; ISS:BHF-UCL. GO:0007269; P:neurotransmitter secretion; IEA:InterPro. GO:0097119; P:postsynaptic density protein 95 clustering; ISS:BHF-UCL. GO:0097104; P:postsynaptic membrane assembly; ISS:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |