UniProt Accession

 PHF13_HUMAN; Q86YI8; B3KUQ7; Q59FB6; Q5TH65; Q8N551; Q9UJP2 

Genbank Protein ID

 AK315110; AK097715; AB209544; AL031447; CH471130; BC032792; BC038516; AL121733 

Genbank Nucleotide ID

 BAG37568.1; BAG53519.1; BAD92781.1; CAI19471.1; EAW71561.1; AAH32792.2; AAH38516.1; CAB57324.1 

Protein Name

 PHD finger protein 13 

Protein Synonyms/Alias

 Survival time-associated PHD finger protein in ovarian cancer 1; SPOC1 

Gene Name

 PHF13 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	EEYSPSCKRRRTVED	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. 

Sequence Annotation

 ZN_FING 232 280 PHD-type.
 REGION 241 248 Interaction with trimethylated histone H3
 MOTIF 110 127 Nuclear localization signal (Probable).  

Keyword

 3D-structure; Cell cycle; Cell division; Chromatin regulator; Complete proteome; DNA condensation; Metal-binding; Mitosis; Nucleus; Polymorphism; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:UniProtKB.
 GO:0035064; F:methylated histone residue binding; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; IMP:UniProtKB.
 GO:0007076; P:mitotic chromosome condensation; IMP:UniProtKB. 

Interpro

 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF00628; PHD 

SMART

 SM00249; PHD 

PROSITE

 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 

PRINTS