CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000683
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centriolar coiled-coil protein of 110 kDa 
Protein Synonyms/Alias
 Centrosomal protein of 110 kDa; CP110; Cep110 
Gene Name
 CCP110 
Gene Synonyms/Alias
 CEP110; CP110; KIAA0419 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
10EYEKFCEKSLARIQEubiquitination[1]
342LESNSDFKVIPTFVTubiquitination[1]
526FGTVSGLKPASMLEKubiquitination[1]
543SLQTELNKSYDVKNPubiquitination[1]
548LNKSYDVKNPSPLLMubiquitination[1]
583FLDNSFEKVKRRLDLubiquitination[1]
597LDIDGLQKENCPYVIubiquitination[1]
639KMLGTSSKESEELLKubiquitination[1]
646KESEELLKSKMLAFEubiquitination[1]
648SEELLKSKMLAFEEMubiquitination[1]
683REQERLQKEIEEQEKubiquitination[2]
801EIQAKFNKITAVAKGubiquitination[1]
819RRLMQTDKLKQLRQTubiquitination[1]
821LMQTDKLKQLRQTVKmethylation[3]
828KQLRQTVKDTMEFIRubiquitination[1]
844FQSEAPLKRGIVSAQubiquitination[1, 2, 4]
917ALSAATQKSLDRKKYubiquitination[1, 2]
940PNKKFLVKQNPSETRubiquitination[1, 2, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. 
Sequence Annotation
 REGION 1 223 CEP97 binding.
 REGION 64 82 Calmodulin-binding.
 REGION 350 565 Interaction with CEP76.
 REGION 781 821 Calmodulin-binding.
 REGION 909 924 Calmodulin-binding.
 MOD_RES 641 641 Phosphoserine.  
Keyword
 Alternative splicing; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1012 AA 
Protein Sequence
MEEYEKFCEK SLARIQEASL STESFLPAQS ESISLIRFHG VAILSPLLNI EKRKEMQQEK 60
QKALDVEARK QVNRKKALLT RVQEILDNVQ VRKAPNASDF DQWEMETVYS NSEVRNLNVP 120
ATFPNSFPSH TEHSTAAKLD KIAGILPLDN EDQCKTDGID LARDSEGFNS PKQCDSSNIS 180
HVENEAFPKT SSATPQETLI SDGPFSVNEQ QDLPLLAEVI PDPYVMSLQN LMKKSKEYIE 240
REQSRRSLRG SINRIVNESH LDKEHDAVEV ADCVKEKGQL TGKHCVSVIP DKPSLNKSNV 300
LLQGASTQAS SMSMPVLASF SKVDIPIRTG HPTVLESNSD FKVIPTFVTE NNVIKSLTGS 360
YAKLPSPEPS MSPKMHRRRS RTSSACHILI NNPINACELS PKGKEQAMDL IIQDTDENTN 420
VPEIMPKLPT DLAGVCSSKV YVGKNTSEVK EDVVLGKSNQ VCQSSGNHLE NKVTHGLVTV 480
EGQLTSDERG AHIMNSTCAA MPKLHEPYAS SQCIASPNFG TVSGLKPASM LEKNCSLQTE 540
LNKSYDVKNP SPLLMQNQNT RQQMDTPMVS CGNEQFLDNS FEKVKRRLDL DIDGLQKENC 600
PYVITSGITE QERQHLPEKR YPKGSGFVNK NKMLGTSSKE SEELLKSKML AFEEMRKRLE 660
EQHAQQLSLL IAEQEREQER LQKEIEEQEK MLKEKKAMTA EASELDINNA VELEWRKISD 720
SSLLETMLSQ ADSLHTSNSN SSGFTNSAMQ YSFVSANEAP FYLWGSSTSG LTKLSVTRPF 780
GRAKTRWSQV FSLEIQAKFN KITAVAKGFL TRRLMQTDKL KQLRQTVKDT MEFIRSFQSE 840
APLKRGIVSA QDASLQERVL AQLRAALYGI HDIFFVMDAA ERMSILHHDR EVRKEKMLRQ 900
MDKMKSPRVA LSAATQKSLD RKKYMKAAEM GMPNKKFLVK QNPSETRVLQ PNQGQNAPVH 960
RLLSRQGTPK TSVKGVVQNR QKPSQSRVPN RVPVSGVYAG KIQRKRPNVA TI 1012 
Gene Ontology
 GO:0005814; C:centriole; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
 GO:0007099; P:centriole replication; IMP:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0032465; P:regulation of cytokinesis; IMP:UniProtKB. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS