UniProt Accession

 IGSF8_HUMAN; Q969P0; Q8NG09; Q96DP4; Q9BTG9 

Genbank Protein ID

 AF407274; AY044845; AY157579; AF311906; AK055843; BC004108; BC053881 

Genbank Nucleotide ID

 AAL01052.1; AAK92220.1; AAO13163.1; AAM94901.1; BAB71027.1; AAH04108.2; AAH53881.1 

Protein Name

 Immunoglobulin superfamily member 8 

Protein Synonyms/Alias

 IgSF8; CD81 partner 3; Glu-Trp-Ile EWI motif-containing protein 2; EWI-2; Keratinocytes-associated transmembrane protein 4; KCT-4; LIR-D1; Prostaglandin regulatory-like protein; PGRL; CD316 

Gene Name

 IGSF8 

Gene Synonyms/Alias

 CD81P3; EWI2; KCT4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
113	QGDAVVLKIARLQAQ	ubiquitination	[1]
143	YLGSYSGKVELRVLP	ubiquitination	[1]
409	GTYRCLAKAYVRGSG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. 

Sequence Annotation

 DOMAIN 28 149 Ig-like C2-type 1.
 DOMAIN 162 286 Ig-like C2-type 2.
 DOMAIN 303 424 Ig-like C2-type 3.
 DOMAIN 431 560 Ig-like C2-type 4.
 MOTIF 274 276 EWI motif.
 LIPID 604 604 S-palmitoyl cysteine (By similarity).
 LIPID 605 605 S-palmitoyl cysteine (By similarity).
 CARBOHYD 50 50 N-linked (GlcNAc...) (Potential).
 CARBOHYD 327 327 N-linked (GlcNAc...).
 CARBOHYD 463 463 N-linked (GlcNAc...).
 DISULFID 49 127 By similarity.
 DISULFID 186 270 By similarity.
 DISULFID 326 406 By similarity.
 DISULFID 462 544 By similarity.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Lipoprotein; Membrane; Palmitate; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 613 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008283; P:cell proliferation; NAS:UniProtKB.
 GO:0006928; P:cellular component movement; NAS:UniProtKB.
 GO:0007399; P:nervous system development; NAS:UniProtKB.
 GO:0007338; P:single fertilization; NAS:UniProtKB.
 GO:0007519; P:skeletal muscle tissue development; NAS:UniProtKB. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 

Pfam

 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS