CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044323
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Leucine-rich repeat serine/threonine-protein kinase 1 
Protein Synonyms/Alias
  
Gene Name
 LRRK1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1234RLFLENSKLEHSEDEubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Leucine-rich repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2012 AA 
Protein Sequence
METLNGAGDT GGKPSTRGGD PAARSRRTEG IRAAYRRGDR GGARDLLEEA CDQCASQLEK 60
GQLLSIPAAY GDLEMVRYLL SKRLVELPTE PTDDNPAVVA AYFGHTAVVQ ELLEPLTPKQ 120
TEWEQTAPFS GTFPLSCHLL PGPCSPQRLL NWMLALACQR GHLGVVKLLV LTHGADPESY 180
AVRKNEFPVI VRLPLYAAIK SGNEDIAIFL LRHGAYFCSY ILLDSPDPSK HLLRKYFIEA 240
SPLPSSYPGK TALRVKWSHL RLPWVDLDWL IDISCQITEL DLSANCLATL PSVIPWGLIN 300
LRKLNLSDNH LGELPGVQSS DEIICSRLLE IDISSNKLSH LPPGFLHLSK LQKLTASKNC 360
LEKLFEEENA TNWIGLRKLQ ELDISDNKLT ELPALFLHSF KSLNSLNVSR NNLKVFPDPW 420
ACPLKCCKAS RNALECLPDK MAVFWKNHLK DVDFSENALK EVPLGLFQLD ALMFLRLQGN 480
QLAALPPQEK WTCRQLKTLD LSRNQLGKNE DGLKTKRIAF FTTRGRQRSG TEAASVLEFP 540
AFLSESLEVL CLNDNHLDTV PPSVCLLKSL SELYLGNNPG LRELPPELGQ LGNLWQLDTE 600
DLTISNVPAE IQKEGPKAML SYLRAQLRKA EKCKLMKMII VGPPRQGKST LLEILQTGRA 660
PQVVHGEATI RTTKWELQRP AGSRAKVESV EFNVWDIGGP ASMATVNQCF FTDKALYVVV 720
WNLALGEEAV ANLQFWLLNI EAKAPNAVVL VVGTHLDLIE AKFRVERIAT LRAYVLALCR 780
SPSGSRATGF PDITFKHLHE ISCKSLEGQE GLRQLIFHVT CSMKDVGSTI GCQRLAGRLI 840
PRSYLSLQEA VLAEQQRRSR DDDVQYLTDR QLEQLVEQTP DNDIKDYEDL QSAISFLIET 900
GTLLHFPDTS HGLRNLYFLD PIWLSECLQR IFNIKGSRSV AKNGVIRAED LRMLLVGTGF 960
TQQTEEQYFQ FLAKFEIALP VANDSYLLPH LLPSKPGLDT HGMRHPTANT IQRVFKMSFV 1020
PVGFWQRFIA RMLISLAEMD LQLFENKKNT KSRNRKVTIY SFTGNQRNRC STFRVKRNQT 1080
IYWQEGLLVT FDGGYLSVES SDVNWKKKKS GGMKIVCQSE VRDFSAMAFI TDHVNSLIDQ 1140
WFPALTATES DGTPLMEQYV PCPVCETAWA QHTDPSEKSE DVQYFDMEDC VLTAIERDFI 1200
SCPRHPDLPV PLQELVPELF MTDFPARLFL ENSKLEHSED EGSVLGQGGS GTVIYRARYQ 1260
GQPVAVKRFH IKKFKNFANV PADTMLRHLR ATDAMKNFSE FRQEASMLHA LQHPCIVALI 1320
GISIHPLCFA LELAPLSSLN TVLSENARDS SFIPLGHMLT QKIAYQIASG LAYLHKKNII 1380
FCDLKSDNIL VWSLDVKEHI NIKLSDYGIS RQSFHEGALG VEGTPGYQAP EIRPRIVYDE 1440
KVDMFSYGMV LYELLSGQRP ALGHHQLQIA KKLSKGIRPV LGQPEEVQFR RLQALMMECW 1500
DTKPEKRPLA LSVVSQMKDP TFATFMYELC CGKQTAFFSS QGQEYTVVFW DGKEESRNYT 1560
VVNTEKGLME VQRMCCPGMK VSCQLQVQRS LWTATEDQKI YIYTLKGMCP LNTPQQALDT 1620
PAVVTCFLAV PVIKKNSYLV LAGLADGLVA VFPVVRGTPK DSCSYLCSHT ANRSKFSIAD 1680
EDARQNPYPV KAMEVVNSGS EVWYSNGPGL LVIDCASLEI CRRLEPYMAP SMVTSVVCSS 1740
EGRGEEVVWC LDDKANSLVM YHSTTYQLCA RYFCGVPSPL RDMFPVRPLD TEPPAASHTA 1800
NPKVPEGDSI ADVSIMYSEE LGTQILIHQE SLTDYCSMSS YSSSPPRQAA RSPSSLPSSP 1860
ASSSSVPFST DCEDSDMLHT PGAASDRSEH DLTPMDGETF SQHLQAVKIL AVRDLIWVPR 1920
RGGDVIVIGL EKDSGAQRGR VIAVLKAREL TPHGVLVDAA VVAKDTVVCT FENENTEWCL 1980
AVWRGWGARE FDIFYQSYEE LGRLEACTRK RR 2012 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR011009; Kinase-like_dom.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR013684; MIRO-like.
 IPR027417; P-loop_NTPase.
 IPR000719; Prot_kinase_cat_dom.
 IPR020859; ROC_GTPase.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF12796; Ank_2
 PF00560; LRR_1
 PF08477; Miro
 PF00069; Pkinase 
SMART
 SM00248; ANK
 SM00369; LRR_TYP 
PROSITE
 PS51450; LRR
 PS50011; PROTEIN_KINASE_DOM
 PS51424; ROC 
PRINTS