CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017623
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial 
Protein Synonyms/Alias
 PDPr 
Gene Name
 PDPR 
Gene Synonyms/Alias
 KIAA1990 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
100RHLTIEQKMADYSNKubiquitination[1, 2, 3, 4]
160PSEIISPKKVAELHHubiquitination[3]
161SEIISPKKVAELHHLubiquitination[5]
310GGFEKNPKPIFTEGKubiquitination[5]
445MPLMYDLKVPRWDFQubiquitination[3]
503EQSKTFYKPDWFDIVubiquitination[3]
745ESRVKLEKGMDFIGRubiquitination[5]
759RDALLQQKQNGVYKRubiquitination[5]
765QKQNGVYKRLTMFILubiquitination[5]
798RNGQYVGKTTSSAYSubiquitination[5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 879 AA 
Protein Sequence
MMFYRLLSIV GRQRASPGWQ NWSSARNSTS AAEARSMALP TQAQVVICGG GITGTSVAYH 60
LSKMGWKDIV LLEQGRLAAG STRFCAGILS TARHLTIEQK MADYSNKLYY QLEQETGIQT 120
GYTRTGSIFL AQTQDRLISL KRINAGLNVI GIPSEIISPK KVAELHHLLN VHDLVGAMHV 180
PEDAVVSSAD VALALASAAS QNGVQIYDRT SVLHVMVKKG QVTGVETDKG QIECQYFVNC 240
AGQWAYELGL SNEEPVSIPL HACEHFYLLT RPLETPLQSS TPTIVDADGR IYIRNWQGGI 300
LSGGFEKNPK PIFTEGKNQL EIQNLQEDWD HFEPLLSSLL RRMPELETLE IMKLVNCPET 360
FTPDMRCIMG ESPAVQGYFV LAGMNSAGLS FGGGAGKYLA EWMVHGYPSE NVWELDLKRF 420
GALQSSRTFL RHRVMEVMPL MYDLKVPRWD FQTGRQLRTS PLYDRLDAQG ARWMEKHGFE 480
RPKYFVPPDK DLLALEQSKT FYKPDWFDIV ESEVKCCKEA VCVIDMSSFT KFEITSTGDQ 540
ALEVLQYLFS NDLDVPVGHI VHTGMLNEGG GYENDCSIAR LNKRSFFMIS PTDQQVHCWA 600
WLKKHMPKDS NLLLEDVTWK YTALNLIGPR AVDVLSELSY APMTPDHFPS LFCKEMSVGY 660
ANGIRVMSMT HTGEPGFMLY IPIEYALHVY NEVMSVGQKY GIRNAGYYAL RSLRIEKFFA 720
FWGQDINNLT TPLECGRESR VKLEKGMDFI GRDALLQQKQ NGVYKRLTMF ILDDHDSDLD 780
LWPWWGEPIY RNGQYVGKTT SSAYSYSLER HVCLGFVHNF SEDTGEEQVV TADFINRGEY 840
EIDIAGYRFQ AKAKLYPVAS LFTQKRRKDD MELSDLHGK 879 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0004047; F:aminomethyltransferase activity; IEA:InterPro.
 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0006546; P:glycine catabolic process; IEA:InterPro.
 GO:0006090; P:pyruvate metabolic process; TAS:Reactome.
 GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; TAS:Reactome. 
Interpro
 IPR006076; FAD-dep_OxRdtase.
 IPR013977; GCV_T_C.
 IPR006222; GCV_T_N.
 IPR027266; TrmE/GcvT_dom1. 
Pfam
 PF01266; DAO
 PF01571; GCV_T
 PF08669; GCV_T_C 
SMART
  
PROSITE
  
PRINTS