| Tag | Content |
|---|
| CPLM ID | CPLM-007322 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Autophagy-related protein 3 |
Protein Synonyms/Alias | Autophagy-related E2-like conjugation enzyme ATG3 |
Gene Name | ATG3 |
Gene Synonyms/Alias | APG3; AUT1; YNR007C; N2040 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 19 | YLTPITHKSTFLTTG | acetylation | [1] | | 48 | CHMFPTWKWNEESSD | acetylation | [1] | | 183 | STSYRVPKMYIVGFN | acetylation | [1] |
|
Reference | [1] Function and molecular mechanism of acetylation in autophagy regulation. Yi C, Ma M, Ran L, Zheng J, Tong J, Zhu J, Ma C, Sun Y, Zhang S, Feng W, Zhu L, Le Y, Gong X, Yan X, Hong B, Jiang FJ, Xie Z, Miao D, Deng H, Yu L. Science. 2012 Apr 27;336(6080):474-7. [ PMID: 22539722] |
Functional Description | E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). |
Sequence Annotation | ACT_SITE 234 234 Glycyl thioester intermediate |
Keyword | 3D-structure; Autophagy; Complete proteome; Cytoplasm; Protein transport; Reference proteome; Transport; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 310 AA |
Protein Sequence | MIRSTLSSWR EYLTPITHKS TFLTTGQITP EEFVQAGDYL CHMFPTWKWN EESSDISYRD 60
FLPKNKQFLI IRKVPCDKRA EQCVEVEGPD VIMKGFAEDG DEDDVLEYIG SETEHVQSTP 120
AGGTKDSSID DIDELIQDME IKEEDENDDT EEFNAKGGLA KDMAQERYYD LYIAYSTSYR 180
VPKMYIVGFN SNGSPLSPEQ MFEDISADYR TKTATIEKLP FYKNSVLSVS IHPCKHANVM 240
KILLDKVRVV RQRRRKELQE EQELDGVGDW EDLQDDIDDS LRVDQYLIVF LKFITSVTPS 300
IQHDYTMEGW 310 |
Gene Ontology | GO:0005829; C:cytosol; IDA:UniProtKB. GO:0019776; F:Atg8 ligase activity; IMP:SGD. GO:0000045; P:autophagic vacuole assembly; IMP:UniProtKB. GO:0006501; P:C-terminal protein lipidation; IDA:SGD. GO:0032258; P:CVT pathway; IMP:SGD. GO:0000422; P:mitochondrion degradation; IMP:SGD. GO:0034727; P:piecemeal microautophagy of nucleus; IMP:SGD. GO:0006612; P:protein targeting to membrane; IMP:UniProtKB. |
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SMART | |
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