| Tag | Content |
|---|
| CPLM ID | CPLM-000040 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Proteinase-activated receptor 3 |
Protein Synonyms/Alias | PAR-3; Coagulation factor II receptor-like 2; Thrombin receptor-like 2 |
Gene Name | F2RL2 |
Gene Synonyms/Alias | PAR3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 374 | HSTAYLTK******* | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. |
Sequence Annotation | CARBOHYD 25 25 N-linked (GlcNAc...) (Potential).
CARBOHYD 82 82 N-linked (GlcNAc...) (Potential).
CARBOHYD 331 331 N-linked (GlcNAc...) (Potential).
DISULFID 166 245 By similarity. |
Keyword | Alternative splicing; Blood coagulation; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Hemostasis; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 374 AA |
Protein Sequence | MKALIFAAAG LLLLLPTFCQ SGMENDTNNL AKPTLPIKTF RGAPPNSFEE FPFSALEGWT 60
GATITVKIKC PEESASHLHV KNATMGYLTS SLSTKLIPAI YLLVFVVGVP ANAVTLWMLF 120
FRTRSICTTV FYTNLAIADF LFCVTLPFKI AYHLNGNNWV FGEVLCRATT VIFYGNMYCS 180
ILLLACISIN RYLAIVHPFT YRGLPKHTYA LVTCGLVWAT VFLYMLPFFI LKQEYYLVQP 240
DITTCHDVHN TCESSSPFQL YYFISLAFFG FLIPFVLIIY CYAAIIRTLN AYDHRWLWYV 300
KASLLILVIF TICFAPSNII LIIHHANYYY NNTDGLYFIY LIALCLGSLN SCLDPFLYFL 360
MSKTRNHSTA YLTK 374 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0005576; C:extracellular region; TAS:Reactome. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:ProtInc. GO:0015057; F:thrombin receptor activity; TAS:ProtInc. GO:0030168; P:platelet activation; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |