UniProt Accession

 CRKL_MOUSE; P47941; Q3TQ18; Q8BGC5 

Genbank Protein ID

 X90648; AK048641; AK052315; AK163981 

Genbank Nucleotide ID

 CAA62220.1; BAC33406.1; BAC34933.1; BAE37567.1 

Protein Name

 Crk-like protein 

Protein Synonyms/Alias

  

Gene Name

 Crkl 

Gene Synonyms/Alias

 Crkol 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
180	IPVPYVEKLVRSSPH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May mediate the transduction of intracellular signals. 

Sequence Annotation

 DOMAIN 14 102 SH2.
 DOMAIN 123 183 SH3 1.
 DOMAIN 235 296 SH3 2.
 MOD_RES 107 107 Phosphoserine.
 MOD_RES 127 127 Phosphotyrosine (By similarity).
 MOD_RES 132 132 Phosphotyrosine.
 MOD_RES 207 207 Phosphotyrosine.
 MOD_RES 251 251 Phosphotyrosine.  

Keyword

 Complete proteome; Phosphoprotein; Reference proteome; Repeat; SH2 domain; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 303 AA 

Protein Sequence

Gene Ontology

 GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
 GO:0001568; P:blood vessel development; IGI:MGI.
 GO:0007507; P:heart development; IGI:MGI.
 GO:0009887; P:organ morphogenesis; IMP:MGI.
 GO:0060017; P:parathyroid gland development; IGI:MGI.
 GO:0048538; P:thymus development; IGI:MGI. 

Interpro

 IPR000980; SH2.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 

Pfam

 PF00017; SH2
 PF00018; SH3_1
 PF07653; SH3_2 

SMART

 SM00252; SH2
 SM00326; SH3 

PROSITE

 PS50001; SH2
 PS50002; SH3 

PRINTS

 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.