UniProt Accession

 IMPA1_HUMAN; P29218; B2R733; B4DLN3; B7Z6Q4; J3KQT7; Q9UK71 

Genbank Protein ID

 X66922; Y11360; Y11361; Y11362; Y11367; Y11363; Y11364; Y11365; Y11366; AF042729; AK297078; AK300750; AK312823; AC090255; CH471068; BC008381; BC009565; AF178754 

Genbank Nucleotide ID

 CAA47359.1; CAA72195.1; CAA72195.1; CAA72195.1; CAA72195.1; CAA72195.1; CAA72195.1; CAA72195.1; CAA72195.1; AAB97468.1; BAG59595.1; BAH13340.1; BAG35680.1; EAW87095.1; AAH08381.1; AAH09565.1; AAD52997.1 

Protein Name

 Inositol monophosphatase 1 

Protein Synonyms/Alias

 IMP 1; IMPase 1; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1 

Gene Name

 IMPA1 

Gene Synonyms/Alias

 IMPA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	NEMNVMLKSSPVDLV	ubiquitination	[1]
49	LVTATDQKVEKMLIS	acetylation	[2]
49	LVTATDQKVEKMLIS	ubiquitination	[1]
52	ATDQKVEKMLISSIK	ubiquitination	[1, 3, 4]
59	KMLISSIKEKYPSHS	ubiquitination	[1]
61	LISSIKEKYPSHSFI	ubiquitination	[1]
145	GAFCNGQKLQVSQQE	ubiquitination	[4]
156	SQQEDITKSLLVTEL	ubiquitination	[1, 4]
181	MVLSNMEKLFCIPVH	ubiquitination	[4]
264	ILAERIAKEIQVIPL	ubiquitination	[1, 4, 5]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates. 

Sequence Annotation

 REGION 92 95 Substrate binding.
 REGION 194 196 Substrate binding.
 METAL 70 70 Magnesium 1.
 METAL 90 90 Magnesium 1.
 METAL 90 90 Magnesium 2.
 METAL 92 92 Magnesium 1; via carbonyl oxygen.
 METAL 93 93 Magnesium 2.
 METAL 220 220 Magnesium 2.
 BINDING 70 70 Substrate.
 BINDING 213 213 Substrate.
 BINDING 220 220 Substrate (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Lithium; Magnesium; Metal-binding; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0008934; F:inositol monophosphate 1-phosphatase activity; IMP:UniProtKB.
 GO:0052832; F:inositol monophosphate 3-phosphatase activity; IEA:EC.
 GO:0052833; F:inositol monophosphate 4-phosphatase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.
 GO:0006661; P:phosphatidylinositol biosynthetic process; IMP:UniProtKB.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
 GO:0007165; P:signal transduction; IMP:UniProtKB. 

Interpro

 IPR020583; Inositol_monoP_metal-BS.
 IPR020552; Inositol_monoPase_Li-sen.
 IPR000760; Inositol_monophosphatase.
 IPR020550; Inositol_monophosphatase_CS. 

Pfam

 PF00459; Inositol_P 

SMART

  

PROSITE

 PS00629; IMP_1
 PS00630; IMP_2 

PRINTS

 PR00377; IMPHPHTASES.
 PR00378; LIIMPHPHTASE.