CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030278
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Potassium voltage-gated channel, shaker-related subfamily, member 2 
Protein Synonyms/Alias
  
Gene Name
 Kcna2 
Gene Synonyms/Alias
 mCG_21725 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
49LRFETQLKTLAQFPEubiquitination[1]
63ETLLGDPKKRMRYFDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Ion channel; Ion transport; Membrane; Potassium; Potassium channel; Potassium transport; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 499 AA 
Protein Sequence
MTVATGDPVD EAAALPGHPQ DTYDPEADHE CCERVVINIS GLRFETQLKT LAQFPETLLG 60
DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR PVNVPLDIFS EEIRFYELGE 120
EAMEMFREDE GYIKEEERPL PENEFQRQVW LLFEYPESSG PARIIAIVSV MVILISIVSF 180
CLETLPIFRD ENEDMHGGGV TFHTYSNSTI GYQQSTSFTD PFFIVETLCI IWFSFEFLVR 240
FFACPSKAGF FTNIMNIIDI VAIIPYFITL GTELAEKPED AQQGQQAMSL AILRVIRLVR 300
VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE ADERDSQFPS 360
IPDAFWWAVV SMTTVGYGDM VPTTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE 420
TEGEEQAQYL QVTSCPKIPS SPDLKKSRSA STISKSDYME IQEGVNNSNE DFREENLKTA 480
NCTLANTNYV NITKMLTDV 499 
Gene Ontology
 GO:0044224; C:juxtaparanode region of axon; IDA:MGI.
 GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
 GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome.
 GO:0015271; F:outward rectifier potassium channel activity; IEA:Compara.
 GO:0021633; P:optic nerve structural organization; IMP:MGI.
 GO:0051260; P:protein homooligomerization; IEA:InterPro. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR003091; K_chnl.
 IPR003968; K_chnl_volt-dep_Kv.
 IPR003972; K_chnl_volt-dep_Kv1.
 IPR004049; K_chnl_volt-dep_Kv1.2.
 IPR003131; T1-type_BTB. 
Pfam
 PF00520; Ion_trans
 PF02214; K_tetra 
SMART
 SM00225; BTB 
PROSITE
  
PRINTS
 PR00169; KCHANNEL.
 PR01509; KV12CHANNEL.
 PR01491; KVCHANNEL.
 PR01496; SHAKERCHANEL.