| Tag | Content |
|---|
| CPLM ID | CPLM-014658 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lanosterol 14-alpha demethylase |
Protein Synonyms/Alias | LDM; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase |
Gene Name | Cyp51a1 |
Gene Synonyms/Alias | Cyp51 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 156 | NAVFLEQKKILKSGL | ubiquitination | [1] | | 436 | DNPASGEKFAYVPFG | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. |
Sequence Annotation | METAL 449 449 Iron (heme axial ligand) (By similarity). |
Keyword | Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Endoplasmic reticulum; Heme; Iron; Lipid biosynthesis; Lipid metabolism; Membrane; Metal-binding; Microsome; Monooxygenase; NADP; Oxidoreductase; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 503 AA |
Protein Sequence | MVLLGLLQSG GSVLGQAMEQ VTGGNLLSTL LIACAFTLSL VYLFRLAVGH MVQLPAGAKS 60
PPYIYSPIPF LGHAIAFGKS PIEFLENAYE KYGPVFSFTM VGKTFTYLLG SDAAALLFNS 120
KNEDLNAEEV YGRLTTPVFG KGVAYDVPNA VFLEQKKILK SGLNIAHFKQ YVSIIEKEAK 180
EYFKSWGESG ERNVFEALSE LIILTASHCL HGKEIRSQLN EKVAQLYADL DGGFSHAAWL 240
LPGWLPLPSF RRRDRAHREI KNIFYKAIQK RRLSKEPAED ILQTLLDSTY KDGRPLTDDE 300
IAGMLIGLLL AGQHTSSTTS AWMGFFLARD KPLQDKCYLE QKTVCGEDLP PLTYEQLKDL 360
NLLDRCIKET LRLRPPIMTM MRMAKTPQTV AGYTIPPGHQ VCVSPTVNQR LKDSWVERLD 420
FNPDRYLQDN PASGEKFAYV PFGAGRHRCI GENFAYVQIK TIWSTMLRLY EFDLINGYFP 480
SVNYTTMIHT PENPVIRYKR RSK 503 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0020037; F:heme binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0008398; F:sterol 14-demethylase activity; IDA:RGD. GO:0033488; P:cholesterol biosynthetic process via 24,25-dihydrolanosterol; IDA:RGD. GO:0045540; P:regulation of cholesterol biosynthetic process; TAS:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |