UniProt Accession

 SCAM5_RAT; Q9JKE3 

Genbank Protein ID

 AF240784 

Genbank Nucleotide ID

 AAF64466.1 

Protein Name

 Secretory carrier-associated membrane protein 5 

Protein Synonyms/Alias

 Secretory carrier membrane protein 5 

Gene Name

 Scamp5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MAEKVNNFPPL	ubiquitination	[1]
185	GSGGSFSKAQEEWTT	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity). 

Sequence Annotation

  

Keyword

 Cell junction; Cell membrane; Complete proteome; Cytoplasmic vesicle; Endosome; Exocytosis; Golgi apparatus; Membrane; Protein transport; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 235 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0000139; C:Golgi membrane; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
 GO:0008021; C:synaptic vesicle; IDA:RGD.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; ISS:UniProtKB.
 GO:0050715; P:positive regulation of cytokine secretion; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR007273; SCAMP. 

Pfam

 PF04144; SCAMP 

SMART

  

PROSITE

  

PRINTS