UniProt Accession

 HAGHL_HUMAN; Q6PII5; A6NCC4; D3DU64; Q59FX8; Q96BZ3; Q96NR5; Q96S11; Q9BT45 

Genbank Protein ID

 AK054841; AE006464; Z98258; CH471112; CH471112; CH471112; CH471112; CH471112; BC004353; BC015008; BC033796; AB209331 

Genbank Nucleotide ID

 BAB70814.1; AAK61250.1; EAW85726.1; EAW85730.1; EAW85731.1; EAW85732.1; EAW85733.1; AAH04353.1; AAH15008.1; AAH33796.1; BAD92568.1 

Protein Name

 Hydroxyacylglutathione hydrolase-like protein 

Protein Synonyms/Alias

  

Gene Name

 HAGHL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
34	AVDVAVPKRLLEIVG	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Hydrolase acting on ester bonds (Potential). 

Sequence Annotation

 METAL 54 54 Zinc 1 (By similarity).
 METAL 56 56 Zinc 1 (By similarity).
 METAL 58 58 Zinc 2 (By similarity).
 METAL 59 59 Zinc 2 (By similarity).
 METAL 110 110 Zinc 1 (By similarity).
 METAL 134 134 Zinc 1 (By similarity).
 METAL 134 134 Zinc 2 (By similarity).
 METAL 172 172 Zinc 2 (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 290 AA 

Protein Sequence

Gene Ontology

 GO:0004416; F:hydroxyacylglutathione hydrolase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006750; P:glutathione biosynthetic process; IEA:InterPro. 

Interpro

 IPR001279; Beta-lactamas-like.
 IPR017782; Hydroxyacylglutathione_Hdrlase. 

Pfam

 PF00753; Lactamase_B 

SMART

 SM00849; Lactamase_B 

PROSITE

  

PRINTS