UniProt Accession

 GBG2_HUMAN; P59768; Q5JPE2; Q6P9A9 

Genbank Protein ID

 AF493870; AL832878; CH471078; BC020774; BC060856 

Genbank Nucleotide ID

 AAM12584.1; CAI46198.1; EAW65663.1; AAH20774.1; AAH60856.1 

Protein Name

 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 

Protein Synonyms/Alias

 G gamma-I 

Gene Name

 GNG2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	IDRIKVSKAAADLMA	ubiquitination	[1]
46	AYCEAHAKEDPLLTP	ubiquitination	[1]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 52 52 Phosphothreonine (By similarity).
 MOD_RES 68 68 Cysteine methyl ester (By similarity).
 LIPID 68 68 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Acetylation; Cell membrane; Complete proteome; Lipoprotein; Membrane; Methylation; Phosphoprotein; Prenylation; Reference proteome; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 71 AA 

Protein Sequence

Gene Ontology

 GO:0005834; C:heterotrimeric G-protein complex; ISS:BHF-UCL.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; ISS:BHF-UCL.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0071870; P:cellular response to catecholamine stimulus; ISS:BHF-UCL.
 GO:0071377; P:cellular response to glucagon stimulus; TAS:Reactome.
 GO:0071380; P:cellular response to prostaglandin E stimulus; ISS:BHF-UCL.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR015898; G-protein_gamma-like_dom.
 IPR001770; Gprotein-gamma. 

Pfam

 PF00631; G-gamma 

SMART

 SM00224; GGL 

PROSITE

 PS50058; G_PROTEIN_GAMMA 

PRINTS

 PR00321; GPROTEING.