CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004168
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tissue factor 
Protein Synonyms/Alias
 TF; Coagulation factor III; Thromboplastin; CD142 
Gene Name
 F3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60TILEWEPKPVNQVYTubiquitination[1]
73YTVQISTKSGDWKSKubiquitination[1]
100DEIVKDVKQTYLARVubiquitination[1, 2]
287AGVGQSWKENSPLNVubiquitination[1, 2, 3, 4]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. 
Sequence Annotation
 MOTIF 46 48 WKS motif.
 MOTIF 77 79 WKS motif.
 MOTIF 190 192 WKS motif.
 LIPID 277 277 S-palmitoyl cysteine.
 CARBOHYD 156 156 N-linked (GlcNAc...) (Potential).
 CARBOHYD 169 169 N-linked (GlcNAc...) (Potential).
 DISULFID 81 89
 DISULFID 218 241  
Keyword
 3D-structure; Alternative splicing; Blood coagulation; Complete proteome; Disulfide bond; Glycoprotein; Hemostasis; Lipoprotein; Membrane; Palmitate; Polymorphism; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 295 AA 
Protein Sequence
METPAWPRVP RPETAVARTL LLGWVFAQVA GASGTTNTVA AYNLTWKSTN FKTILEWEPK 60
PVNQVYTVQI STKSGDWKSK CFYTTDTECD LTDEIVKDVK QTYLARVFSY PAGNVESTGS 120
AGEPLYENSP EFTPYLETNL GQPTIQSFEQ VGTKVNVTVE DERTLVRRNN TFLSLRDVFG 180
KDLIYTLYYW KSSSSGKKTA KTNTNEFLID VDKGENYCFS VQAVIPSRTV NRKSTDSPVE 240
CMGQEKGEFR EIFYIIGAVV FVVIILVIIL AISLHKCRKA GVGQSWKENS PLNVS 295 
Gene Ontology
 GO:0031012; C:extracellular matrix; IDA:BHF-UCL.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0031233; C:intrinsic to external side of plasma membrane; IC:BHF-UCL.
 GO:0005543; F:phospholipid binding; IDA:BHF-UCL.
 GO:0002543; P:activation of blood coagulation via clotting cascade; IC:BHF-UCL.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
 GO:0002541; P:activation of plasma proteins involved in acute inflammatory response; IDA:BHF-UCL.
 GO:0007598; P:blood coagulation, extrinsic pathway; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; TAS:BHF-UCL.
 GO:0045766; P:positive regulation of angiogenesis; IDA:BHF-UCL.
 GO:0030335; P:positive regulation of cell migration; TAS:BHF-UCL.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:BHF-UCL.
 GO:0010641; P:positive regulation of platelet-derived growth factor receptor signaling pathway; IDA:BHF-UCL.
 GO:0050927; P:positive regulation of positive chemotaxis; IC:BHF-UCL.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:BHF-UCL. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR015373; Interferon_alpha/beta_rcpt_bsu.
 IPR016354; Tissue_fac/coagulation_fac-3.
 IPR001187; Tissue_factor. 
Pfam
 PF09294; Interfer-bind 
SMART
  
PROSITE
 PS00621; TISSUE_FACTOR 
PRINTS
 PR00346; TISSUEFACTOR.