CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015172
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrator complex subunit 1 
Protein Synonyms/Alias
 Int1 
Gene Name
 Ints1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1873DANMACRKLAVAHPVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). 
Sequence Annotation
 MOD_RES 47 47 N6-acetyllysine (By similarity).
 MOD_RES 307 307 Phosphoserine (By similarity).
 MOD_RES 1320 1320 Phosphoserine (By similarity).
 MOD_RES 1328 1328 Phosphoserine.
 MOD_RES 1329 1329 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2195 AA 
Protein Sequence
MNRAKPTTVR RPSAAAKPSG HPPPGDFIAL GSKGQASESK TTSTLLKPAP SGLPSERKRD 60
ASASLSGTSA LTGLTKRPKL SSTPPLSALG RLAEAAVAEK RAISPSIKEP SVVPIEVLPT 120
VLLDEIEAAE LEGNDDRIEG VLCGAVKQLK VTRAKPDSTL YLSLMYLAKI KPNIFATEGV 180
IEALCSLLRR DASVNFKAKG NSLVSVLACN LLMAAYEEDE NWPEIFVKVY IEDSLGERIW 240
VDSPHCRTFV DNIQTAFNTK MPPKSVLLQG EGARSGGELG AGSSPHPSLT EEEDSQTELL 300
IAEEKLSPEQ EGQLMPRPRY DELTESVEEY VLDMLRDQLN RRQPIDNVSR NLLRLLTATC 360
GYKEVRLLAV QRLEMWLQNP KLTRPAQDLL MSVCMNCNSH GSEDMDVISH LIKIRLKPKV 420
LLNHYMLCIR ELLNAHKDNL GTTIKFVIFN ELSNARNPNN MQILYTVLQH SSELAPKFLA 480
MVFQDLLTNK DDYLRASRAL LREIIKQTKH EINFQAFCLG LMQERKEPQY LEMEFKERFV 540
VHITDVLAVS MMLGITAQVK EAGVAWDKGE KRNLEVLRTF QNQIAAIQRD AVWWLHTVVP 600
SVSKLAPKDY VHCLHKVLFT EQPETYYKWD NWPPESDRNF FLRLCSEVPI LEDTLMRVLV 660
IGLSRELPLG PADAMELADH LVKRAAAVQA DDVEVLKVER IQLIDAVLNL CTYHHPENIQ 720
LPPGYQPPNL AISTLYWKAW PLLLVVAAFN PENIGLAAWE EYPTLKMLME MVMTNNYSYP 780
PCTLTDEETR TEMINRELQI SQREKQEILA FEGHLAAAST KQTITESSSL LLSQLTSLDP 840
QGPPRRPPPH ILDQVKALNQ SLRLGHLLCR SRNPDFLLHI IQRQASSQSM PWLADLVQSS 900
EGSLDVLPVQ CLCEFLLHDA ADSTASGEED DEGESREQKA KKRQRQQKQR QLLGRLQDLL 960
LGPKADEQTT CEVLDYFLRR LGSSQVASRV LAMKGLSLVL SEGGLRDKEE KEPPMEEDIG 1020
ETDALQGYQW LLRDLPRLPL FDSVRTTTAL ALQQAIHMET DPQTISAYLI YLSQHTPVEE 1080
QGPHSDLALD VARLVVERST IMAHLFSKPS CSTASDAVLS ALLSVFSRYV RRMRKSKEGE 1140
EVYSWSESQD QVFLRWSSGE TATMHILVVH AMVILLTLGP PRSGDSEFSE LLDIWFPEKK 1200
PLPTAFLVDT SEEALLLPDW LKLRMIRSEV PRLVDAALQD LEPQQLLLFV QSFGIPVSSM 1260
SKLLQYLDQA VAQDPQTLEQ NIMDKNYMAH LVEVQHERGA SGGQTFHSLL TASLPPRRDS 1320
TEAPKPESSP EPPPGQGRTR AGTQVPVLGP EDDLAGIFLQ IFPLSPDPRW QSSSPRPLAL 1380
ALQQALGQEL ARVRQGNPEV PGITVRLLQA MTTLLSSPHG GTLALAMHHS HFLSCPLMRQ 1440
LYQYQRAVPQ DTGFSSLFLK VLMQILQWLD SPAVEDGPLQ AQLKLFATRY SARHRISDVR 1500
SGLLHLADAL SFHGDLEVAN STARAVIATL RSGEKCPVEP ELISKVLRGL IEVRSPHLEE 1560
LLTALFSATT ETSCPSPASG PIVVVSSLLL QEKEELLGPS KQEVEGASTE AMRLGPASGL 1620
LVDWLETLDP EVVCSCPDLQ WKLLFSRRKG KGHISAQVLS FRPYLLALLT HQASWSTLHC 1680
CIRVLLGKSR EQRLDPSASL DFLWACIHVP RIWQGRDQRT PQKRREELVL HVQGPELLSL 1740
VELILSEAET RSQDGDSAAR TLIQTRLPLL LSCCRSNDES IGKVTEHLTS CIQQWGDSVL 1800
GQRCRDLLLQ LYLQRPEVRV PVPEVLLQSE GATSSSICKL DGLVHRFITL LADTSDSRSS 1860
ESRVADANMA CRKLAVAHPV LLLRHLPMIA ALLHGRTHLN FQEFRQQNHL AFFLHVLGIL 1920
ELLQPRVFQS EHQGALWDCL RSFIRLLLNY RKSSRHLAPF ISKFVQFIHK YVGCSAPAAV 1980
AFLQKHAEPL HDLSFDNSDL VMLKSLLAGL SLPSRDGRTD QGLDEEGEDE RSAGSLPLVS 2040
VSLSTPLTVA DVAPHMKRLS RGRAVEDVLE TLSDIDEMSR RRPEVLGFFS TNLQRLMSSA 2100
EESCRNLAFS LALRSIQNNP SIAADFLPTF MYCLGSRDFE VVQTALRNLP EYTLLCQEHA 2160
AVLLHRAFLV GVYGQIDTSA QISEALKILH MEAVM 2195 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0032039; C:integrator complex; IEA:Compara.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0001833; P:inner cell mass cell proliferation; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:MGI.
 GO:0034474; P:U2 snRNA 3'-end processing; IMP:MGI. 
Interpro
 IPR022145; DUF3677. 
Pfam
 PF12432; DUF3677 
SMART
  
PROSITE
  
PRINTS