CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027376
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock 70 kDa protein 
Protein Synonyms/Alias
  
Gene Name
 PF08_0054 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
149NAEAFLGKSIKNAVIacetylation[1]
258NFCVEDFKRKNRGKDacetylation[1]
364PKIQTLIKEFFNGKEacetylation[1]
471KDNNLLGKFHLDGIPacetylation[1]
537RMVNDAEKYKAEDEEacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 677 AA 
Protein Sequence
MASAKGSKPN LPESNIAIGI DLGTTYSCVG VWRNENVDII ANDQGNRTTP SYVAFTDTER 60
LIGDAAKNQV ARNPENTVFD AKRLIGRKFT ESSVQSDMKH WPFTVKSGVD EKPMIEVTYQ 120
GEKKLFHPEE ISSMVLQKMK ENAEAFLGKS IKNAVITVPA YFNDSQRQAT KDAGTIAGLN 180
VMRIINEPTA AAIAYGLHKK GKGEKNILIF DLGGGTFDVS LLTIEDGIFE VKATAGDTHL 240
GGEDFDNRLV NFCVEDFKRK NRGKDLSKNS RALRRLRTQC ERAKRTLSSS TQATIEIDSL 300
FEGIDYSVTV SRARFEELCI DYFRDTLIPV EKVLKDAMMD KKSVHEVVLV GGSTRIPKIQ 360
TLIKEFFNGK EACRSINPDE AVAYGAAVQA AILSGDQSNA VQDLLLLDVC SLSLGLETAG 420
GVMTKLIERN TTIPAKKSQI FTTYADNQPG VLIQVYEGER ALTKDNNLLG KFHLDGIPPA 480
PRKVPQIEVT FDIDANGILN VTAVEKSTGK QNHITITNDK GRLSQDEIDR MVNDAEKYKA 540
EDEENRKRIE ARNSLENYCY GVKSSLEDQK IKEKLQPAEI ETCMKTITTI LEWLEKNQLA 600
GKDEYEAKQK EAESVCAPIM SKIYQDAAGA AGGMPGGMPG GMPGGMPGGM NFPGGMPGAG 660
MPGNAPAGSG PTVEEVD 677 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0009408; P:response to heat; ISS:GeneDB_Pfalciparum.
 GO:0006986; P:response to unfolded protein; ISS:GeneDB_Pfalciparum. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.