CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040342
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nicastrin 
Protein Synonyms/Alias
  
Gene Name
 NCSTN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
110FTRDLMEKLKGRTSRubiquitination[1]
127GLAVSLTKPSPASGFubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 571 AA 
Protein Sequence
MATAGGGSGA DPGSRGLLRL LSFCVLLAGL CRGNSVERKI YIPLNKTAPC VRLLNATHQI 60
GCQSSISGDT GVIHVVEKEE DLQWVLTDGP NPPYMVLLES KHFTRDLMEK LKGRTSRIAG 120
LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN SYGPEFAHCR EIQWNSLGNG LAYEDFSFPI 180
FLLEDENETK VIKQETFDYI GSSRMVYDME KGKFPVQLEN VDSFVELGQV ALRTSLELWM 240
HTDPVSQKNE SVRNQVEDLL ATLEKSGAGV PAVILRRPNQ SQPLPPSSLQ RFLRARNISG 300
VVLADHSGAF HNKYYQSIYD TAENINVSYP EWLSPEEDLN FVTDTAKALA DVATVLGRAL 360
YELAGGTNFS DTVQADPQTV TRLLYGFLIK ANNSWFQSIL RQDLRSYLGD GPLQHYIAVS 420
SPTNTTYVVQ YALANLTGTV VNLTREQCQD PSKVPSENKD LYEYSWVQGP LHSNETDRLP 480
RCVRSTARLA RALSPAFELS QWSSTEYSTW TESRWKDIRA RIFLIASKEL ELITLTVGFG 540
ILIFSLIVTY CINAKADVLF IAPREPGAVS Y 571 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0016485; P:protein processing; IEA:InterPro. 
Interpro
 IPR008710; Nicastrin. 
Pfam
 PF05450; Nicastrin 
SMART
  
PROSITE
  
PRINTS