UniProt Accession

 MEMO1_HUMAN; Q9Y316; B4DLS0; D6W575; Q5R2V9; Q6NSL5 

Genbank Protein ID

 AF363446; AB041018; AF529368; AF132961; AK297128; AL121652; AL121655; CH471053; CH471053; CH471053; CH471053; BC018733; BC070046; BC094681 

Genbank Nucleotide ID

 AAL34462.1; BAD74066.1; AAQ09602.1; AAD27736.1; BAG59632.1; EAX00467.1; EAX00469.1; EAX00470.1; EAX00472.1; AAH18733.1; AAH70046.1; AAH94681.1 

Protein Name

 Protein MEMO1 

Protein Synonyms/Alias

 C21orf19-like protein; Hepatitis C virus NS5A-transactivated protein 7; HCV NS5A-transactivated protein 7; Mediator of ErbB2-driven cell motility 1; Mediator of cell motility 1; Memo-1 

Gene Name

 MEMO1 

Gene Synonyms/Alias

 C2orf4; MEMO; NS5ATP7; CGI-27 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
108	YDLRIDQKIYGELWK	ubiquitination	[1]
115	KIYGELWKTGMFERM	ubiquitination	[1, 2]
148	AKAMESHKDEFTIIP	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. 

Sequence Annotation

 MOD_RES 210 210 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0032886; P:regulation of microtubule-based process; IMP:UniProtKB. 

Interpro

 IPR002737; UPF0103/Memo-related. 

Pfam

 PF01875; Memo 

SMART

  

PROSITE

  

PRINTS