CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015294
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetratricopeptide repeat protein 37 
Protein Synonyms/Alias
 TPR repeat protein 37; SKI3 homolog; Ski3; Tricho-hepatic-enteric syndrome protein; Thespin 
Gene Name
 TTC37 
Gene Synonyms/Alias
 KIAA0372 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
114YESVDKQKWCDVCKKubiquitination[1]
334LSCSQALKIVDNLGAubiquitination[1]
362LKAEALIKLSDYDSSubiquitination[2]
392IPGLLVLKSLAYRNKubiquitination[1, 2]
441KDYLQAEKCFQRALEubiquitination[1]
596AALRADPKDFNCWESubiquitination[1]
619GGYTTALKSFTKASEubiquitination[3, 4]
647AIQQILGKYKEAVAQubiquitination[1]
691LVDYLDGKAVDYIEKubiquitination[1]
755EGKQVLKKNELLHLGubiquitination[1]
1038CSTGEYDKAIQAFKSubiquitination[1]
1354TLCTKNLKSNPDQPAubiquitination[1]
1516VYQPGYPKSIASTARubiquitination[1, 3, 4]
1547DVLVNNAKTHGDTRAubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). 
Sequence Annotation
 REPEAT 6 39 TPR 1.
 REPEAT 40 73 TPR 2.
 REPEAT 272 305 TPR 3.
 REPEAT 307 339 TPR 4.
 REPEAT 386 419 TPR 5.
 REPEAT 420 453 TPR 6.
 REPEAT 455 492 TPR 7.
 REPEAT 493 527 TPR 8.
 REPEAT 564 597 TPR 9.
 REPEAT 598 631 TPR 10.
 REPEAT 633 665 TPR 11.
 REPEAT 679 713 TPR 12.
 REPEAT 790 824 TPR 13.
 REPEAT 826 860 TPR 14.
 REPEAT 861 894 TPR 15.
 REPEAT 980 1013 TPR 16.
 REPEAT 1020 1054 TPR 17.
 REPEAT 1056 1084 TPR 18.
 REPEAT 1326 1359 TPR 19.
 REPEAT 1400 1433 TPR 20.  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1564 AA 
Protein Sequence
MSSKEVKTAL KSARDAIRNK EYKEALKHCK TVLKQEKNNY NAWVFIGVAA AELEQPDQAQ 60
SAYKKAAELE PDQLLAWQGL ANLYEKYNHI NAKDDLPGVY QKLLDLYESV DKQKWCDVCK 120
KLVDLYYQEK KHLEVARTWH KLIKTRQEQG AENEELHQLW RKLTQFLAES TEDQNNETQQ 180
LLFTAFENAL GLSDKIPSED HQVLYRHFIQ SLSKFPHESA RLKKACEGMI NIYPTVQYPL 240
EVLCLHLIES GNLTDEGQQY CCRLVEMDSK SGPGLIGLGI KALQDKKYED AVRNLTEGLK 300
ESPVCTSGWY HLAEAQVKMH RPKEAVLSCS QALKIVDNLG ASGNSLYQRN LCLHLKAEAL 360
IKLSDYDSSE EAIRTLDQIS DADNIPGLLV LKSLAYRNKG SFDEAAKIME DLLSSYPDLA 420
EVHALEALIH FTKKDYLQAE KCFQRALEKD TEVAEYHYQL GLTYWFMGEE TRKDKTKALT 480
HFLKAARLDT YMGKVFCYLG HYYRDVVGDK NRARGCYRKA FELDDTDAES GAAAVDLSVE 540
LEDMEMALAI LTTVTQKASA GTAKWAWLRR GLYYLKAGQH SQAVADLQAA LRADPKDFNC 600
WESLGEAYLS RGGYTTALKS FTKASELNPE SIYSVFKVAA IQQILGKYKE AVAQYQMIIK 660
KKEDYVPALK GLGECHLMMA KAALVDYLDG KAVDYIEKAL EYFTCALQHR ADVSCLWKLA 720
GDACTCLYAV APSKVNVHVL GVLLGQKEGK QVLKKNELLH LGGRCYGRAL KLMSTSNTWC 780
DLGINYYRQA QHLAETGSNM NDLKELLEKS LHCLKKAVRL DSNNHLYWNA LGVVACYSGI 840
GNYALAQHCF IKSIQSEQIN AVAWTNLGVL YLTNENIEQA HEAFKMAQSL DPSYLMCWIG 900
QALIAEAVGS YDTMDLFRHT TELNMHTEGA LGYAYWVCTT LQDKSNRETE LYQYNILQMN 960
AIPAAQVILN KYVERIQNYA PAFTMLGYLN EHLQLKKEAA NAYQRAILLL QTAEDQDTYN 1020
VAIRNYGRLL CSTGEYDKAI QAFKSTPLEV LEDIIGFALA LFMKGLYKES SKAYERALSI 1080
VESEQDKAHI LTALAITEYK QGKTDVAKTL LFKCSILKEP TTESLQALCA LGLAMQDATL 1140
SKAALNELLK HIKHKDSNYQ RCLLTSAIYA LQGRSVAVQK QISKAVHSNP GDPALWSLLS 1200
RVVAQYAQRN AKGGVVAGNV AHILDSNHGK KALLYTAVNQ LAMGSSSAED EKNTALKTIQ 1260
KAALLSPGDP AIWAGLMAAC HADDKLALVN NTQPKRIDLY LALLSAVSAS IKDEKFFENY 1320
NQSLEKWSLS QAVTGLIDTG RISEAETLCT KNLKSNPDQP AVILLLRQVQ CKPLLESQKP 1380
LPDAVLEELQ KTVMSNSTSV PAWQWLAHVY QSQGMMRAAE MCYRKSLQLA SQRGSWSGKL 1440
SSLLRLALLA LKVCMANISN DHWPSLVQEA TTEALKLCFC PLAVLLQALL QFKRKMGARE 1500
TRRLLERVVY QPGYPKSIAS TARWYLLRHL YAKDDYELID VLVNNAKTHG DTRALELNQR 1560
LSSQ 1564 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0055087; C:Ski complex; IDA:UniProtKB.
 GO:0035327; C:transcriptionally active chromatin; IDA:UniProtKB. 
Interpro
 IPR006597; Sel1-like.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1
 PF13181; TPR_8 
SMART
 SM00671; SEL1
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS