UniProt Accession

 EAF1_HUMAN; Q96JC9; Q8IW10 

Genbank Protein ID

 AF272973; BC041329 

Genbank Nucleotide ID

 AAK58687.1; AAH41329.1 

Protein Name

 ELL-associated factor 1 

Protein Synonyms/Alias

  

Gene Name

 EAF1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	RLGESFEKRPRASFH	ubiquitination	[1]
150	MPFRAPTKPPVGPKT	acetylation	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. 

Sequence Annotation

 REGION 182 262 Necessary for transactivation activity.
 MOD_RES 158 158 Phosphoserine (By similarity).
 MOD_RES 165 165 Phosphoserine.  

Keyword

 Activator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 268 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
 GO:0032783; C:ELL-EAF complex; IEA:InterPro.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR027093; EAF_fam.
 IPR019194; Tscrpt_elong_fac_Eaf_N. 

Pfam

 PF09816; EAF 

SMART

  

PROSITE

  

PRINTS